About: The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo

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About: The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo
Creator	Weng, Ching-Feng Chang, Chia-Hsiang Chen, Jian-Chyi Cheng, Henrich Lin, Shian-Ren »more»
source	Medline; PMC
abstract	Dipeptidyl peptidase IV (DPP-4), an incretin glucagon-like peptide-1 (GLP-1) degrading enzyme, contains two forms and it can exert various physiological functions particular in controlling blood glucose through the action of GLP-1. In diabetic use, the DPP-4 inhibitor can block the DDP-4 to attenuate GLP-1 degradation and prolong GLP-1 its action and sensitize insulin activity for the purpose of lowering blood glucose. Nonetheless the adverse effects of DPP-4 inhibitors severely hinder their clinical applications, and notably there is a clinical demand for novel DPP-4 inhibitors from various sources including chemical synthesis, herbs, and plants with fewer side effects. In this review, we highlight various strategies, namely computational biology (in silico), in vitro enzymatic and cell assays, and in vivo animal tests, for seeking natural DPP-4 inhibitors from botanic sources including herbs and plants. The pros and cons of all approaches for new inhibitor candidates or hits will be under discussion.
has issue date	2019-09-19(xsd:dateTime)
bibo:doi	10.1177/2040622319875305
bibo:pmid	31555430
has license	cc-by-nc
sha1sum (hex)	570064e6a308ec28efcc76ef74ba3f0e6ea5e5a5
schema:url	https://doi.org/10.1177/2040622319875305
resource representing a document's title	The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivo
has PubMed Central identifier	PMC6753520
has PubMed identifier	31555430
schema:publication	Ther Adv Chronic Dis
resource representing a document's body	covid:570064e6a308ec28efcc76ef74ba3f0e6ea5e5a5#body_text
is schema:about of	named entity 'APPLICATIONS' named entity 'VARIOUS' named entity 'DISCUSSION' named entity 'ADVERSE EFFECTS' named entity 'HERBS' »more»

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