About: 2019 Novel-coronavirus: Cardiovascular Insights about Risk Factors, Myocardial Injury, Therapy and Clinical Implications

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About: 2019 Novel-coronavirus: Cardiovascular Insights about Risk Factors, Myocardial Injury, Therapy and Clinical Implications Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	2019 Novel-coronavirus: Cardiovascular Insights about Risk Factors, Myocardial Injury, Therapy and Clinical Implications
Creator	Anastasia, Gianluca Aspromonte, Nadia Cappannoli, Luigi Di Giusto, Federico Giusto, Federico »more»
source	Elsevier; Medline; PMC
abstract	From December 31th, 2019, a novel highly pathogenic coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide, reaching at present the dimension of a pandemic. In addition to damaging the lungs, SARS-CoV-2 may also damage the heart and this is corroborated by the evidence that cardiovascular comorbidities are associated with a higher mortality and poor clinical outcomes in patient infected by the virus. During the infection myocardial injury, myocarditis and arrhythmias have also been reported, but the pathophysiological mechanisms of these complications are yet to be understood. Great attention is also being posed on the potential beneficial/harmful role of angiotensin converting enzyme (ACE) inhibitors, as far as the virus binds to angiotensin converting enzyme 2 (ACE2) to infect cells, but evidences lack. Furthermore, SARS-CoV-2 can also affect the aspect of acute coronary syndromes, not only because these two distinct pathological entities share pathogenic aspects (such as the systemic inflammatory state and cytokine release), but also and above all for the consequences that the need to contain the infection has on the management of cardiological urgencies. Aim of this review is therefore to summarize the relationship between the virus and the cardiovascular system.
has issue date	2020-06-13(xsd:dateTime)
bibo:doi	10.1016/j.cdtm.2020.06.002
bibo:pmid	32837764
has license	no-cc
sha1sum (hex)	566553ca1e9e85caa6f0477b9c1674aa6dd5a717
schema:url	https://doi.org/10.1016/j.cdtm.2020.06.002
resource representing a document's title	2019 Novel-coronavirus: Cardiovascular Insights about Risk Factors, Myocardial Injury, Therapy and Clinical Implications
has PubMed Central identifier	PMC7293466
has PubMed identifier	32837764
schema:publication	Chronic Dis Transl Med
resource representing a document's body	covid:566553ca1e9e85caa6f0477b9c1674aa6dd5a717#body_text
is schema:about of	named entity 'enzyme' named entity 'pathological' named entity 'complications' named entity 'BINDS' named entity 'RELATIONSHIP' »more»

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