About: Structural basis for the recognition of the 2019-nCoV by human ACE2

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Structural basis for the recognition of the 2019-nCoV by human ACE2
Creator	Guo, Yingying Xia, Lu Zhang, Yuanyuan Zhou, Qiang Yan, Renhong
source	BioRxiv; MedRxiv
abstract	Angiotensin-converting enzyme 2 (ACE2) has been suggested to be the cellular receptor for the new coronavirus (2019-nCoV) that is causing the coronavirus disease 2019 (COVID-19). Like other coronaviruses such as the SARS-CoV, the 2019-nCoV uses the receptor binding domain (RBD) of the surface spike glycoprotein (S protein) to engage ACE2. We most recently determined the structure of the full-length human ACE2 in complex with a neutral amino acid transporter B0AT1. Here we report the cryo-EM structure of the full-length human ACE2 bound to the RBD of the 2019-nCoV at an overall resolution of 2.9 Å in the presence of B0AT1. The local resolution at the ACE2-RBD interface is 3.5 Å, allowing analysis of the detailed interactions between the RBD and the receptor. Similar to that for the SARS-CoV, the RBD of the 2019-nCoV is recognized by the extracellular peptidase domain (PD) of ACE2 mainly through polar residues. Pairwise comparison reveals a number of variations that may determine the different affinities between ACE2 and the RBDs from these two related viruses.
has issue date	2020-02-20(xsd:dateTime)
bibo:doi	10.1101/2020.02.19.956946
has license	biorxiv
sha1sum (hex)	563ba81d1b21b4937166a4f5976767ce7be69f9f
schema:url	https://doi.org/10.1101/2020.02.19.956946
resource representing a document's title	Structural basis for the recognition of the 2019-nCoV by human ACE2
schema:publication	bioRxiv
resource representing a document's body	covid:563ba81d1b21b4937166a4f5976767ce7be69f9f#body_text
is schema:about of	named entity 'engage' named entity 'acid' named entity 'structure' named entity 'binding domain' named entity 'RESOLUTION' »more»

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