About: Tamoxifen reduces inflammatory infiltration of neutrophils in the airways

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Tamoxifen reduces inflammatory infiltration of neutrophils in the airways
Creator	Flores, Carlos Henríquez, Claudio Mall, Marcus Mansilla, Agustín Philp, Amber »more»
source	BioRxiv
abstract	Tamoxifen is a drug of choice for treatment of breast cancer but it has also been reported to bear anti-inflammatory activity. Previously, we have observed that tamoxifen treatment successfully reduced inflammation in horses affected by equine asthma syndrome. More notorious, tamoxifen was effective at reducing the infiltration of neutrophils in the inflamed airways by a mechanism that increases efferocytosis, allowing the resolution of inflammation. Due to the emerging increase in patients with chronic inflammatory lung diseases, there is an urgent need for therapies that help reduce airway inflammation. Thus we tested the effect of tamoxifen on airway neutrophil infiltration by using three different mouse models for acute and chronic inflammation of the lung. We found that the drug was able to produce a significant reduction in neutrophils in all scenarios. Ussing chamber experiments demonstrated that tamoxifen has no effect on fluid secretion and absorption, discarding a possible reduction in mucociliary clearance due to the known ion-channel blocking effects of tamoxifen. Since this drug has been largely used in human medicine, tamoxifen might be a “low hanging fruit” for a novel anti-inflammatory therapy for airway diseases characterized by neutrophilic inflammation.
has issue date	2020-06-20(xsd:dateTime)
bibo:doi	10.1101/2020.06.19.161919
has license	biorxiv
sha1sum (hex)	51f4e61b393259a96ea65efc95b68e5909a5c72e
schema:url	https://doi.org/10.1101/2020.06.19.161919
resource representing a document's title	Tamoxifen reduces inflammatory infiltration of neutrophils in the airways
schema:publication	bioRxiv
resource representing a document's body	covid:51f4e61b393259a96ea65efc95b68e5909a5c72e#body_text
is schema:about of	named entity 'diseases' named entity 'effective' named entity 'infiltration' named entity 'NEUTROPHILS' named entity 'ABSORPTION' »more»

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