About: Antiviral activity of Carbenoxolone disodium against dengue virus infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Antiviral activity of Carbenoxolone disodium against dengue virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Antiviral activity of Carbenoxolone disodium against dengue virus infection
Creator	He, Li Huang, Xi Zhang, Ping Yang, Zhicong Li, Yuye »more»
source	Medline; PMC
abstract	As one of the most important mosquito‐borne viral diseases, dengue infection is now becoming a global concern due to its rapid spread and rise in incidence. Currently, there is no approved vaccine or effective antiviral drug for dengue virus (DENV) infection. Glycyrrhetinic acid (GNa) and its related derivatives have been reported to inhibit a broad spectrum of viruses. However, it is unknown whether Carbenoxolone disodium (CBX), one of the GNa derivatives, affects DENV infection. Here, we found that the production of infectious DENV particles was significantly decreased by CBX treatment in DENV‐permissive cells, while the viral RNA and viral protein synthesis were not affected. Moreover, results from time‐of‐addition study showed that the inhibitory effect of CBX on DENV was exhibited by targeting the virus itself, not the host cells. Directly incubating DENV with CBX resulted in a remarkable reduction of virus titer and virus infectivity. Furthermore, DENV RNA from progeny virions in the supernatants was significantly decreased by CBX treatment in a dose‐dependent manner. Taken together, these data indicate that the antiviral activity of CBX against DENV may be mainly due to a virucidal effect exerted by the compound itself. Our work, for the first time, demonstrates that CBX has antiviral activity against DENV infection, providing useful information for development of potential therapeutic interventions against dengue. J. Med. Virol. 89:571–581, 2017. © 2016 Wiley Periodicals, Inc.
has issue date	2016-12-23(xsd:dateTime)
bibo:doi	10.1002/jmv.24571
bibo:pmid	27155198
has license	no-cc
sha1sum (hex)	50cae8bd5dfed34526905abc62b06df051a3d767
schema:url	https://doi.org/10.1002/jmv.24571
resource representing a document's title	Antiviral activity of Carbenoxolone disodium against dengue virus infection
has PubMed Central identifier	PMC7167157
has PubMed identifier	27155198
schema:publication	J Med Virol
resource representing a document's body	covid:50cae8bd5dfed34526905abc62b06df051a3d767#body_text
is schema:about of	named entity 'particles' named entity 'production' named entity 'effective' named entity 'development' named entity 'Here' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software