About: A heterologous ‘prime‐boost’ anti‐PEDV immunization for pregnant sows protects neonatal piglets through lactogenic immunity against PEDV

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About: A heterologous ‘prime‐boost’ anti‐PEDV immunization for pregnant sows protects neonatal piglets through lactogenic immunity against PEDV Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A heterologous ‘prime‐boost’ anti‐PEDV immunization for pregnant sows protects neonatal piglets through lactogenic immunity against PEDV
Creator	Cao, Y Chen, L Li, W Wen, Z Xu, Z »more»
source	Medline; PMC
abstract	ABSTRACT: Porcine epidemic diarrhoea virus (PEDV) causes severe diarrhoea in neonatal suckling piglets with a high mortality. Maternal vaccines that can induce lactogenic immunity to protect suckling piglets via colostrums and milk are pivotal for the prevention and control of PEDV infection in neonatal suckling piglets. In this study, a group of pregnant sows were first orally immunized with coated PEDV‐loaded microspheres and boosted with killed PEDV vaccines (heterologous prime‐boost). It has been detected that the levels of PEDV‐specific antibodies (IgG and IgA) in their sera and milks were higher than other negative groups (P < 0·001 or P < 0·05). Furthermore, it has been proved by the neutralization assay that the induced antibodies could significantly inhibit virus infection as compared to other negative groups (P < 0·01 or P < 0·05). Importantly, after PEDV challenge, more than 90% of the suckling piglets delivered by the sows in the heterologous prime‐boost group were completely protected. Overall, the results show that ‘heterologous prime‐boost’ form is an efficient and effective way to provide protection for suckling piglets against PEDV through lactogenic immunity. SIGNIFICANCE AND IMPACT OF THE STUDY: As a widespread swine pathogen, PEDV affects the swine industry enormously. It causes enteritis in swine of all ages and is often fatal in neonatal piglets. Our data show that pregnant sows were immunized with ‘coated PEDV‐loaded microspheres + killed PEDV vaccines’ (heterologous prime‐boost immunization) could protect more than 90% suckling piglets delivered by the sows against the virus. These findings provide a new model of developing safe and effective immunizations for newborn animals against established and emerging enteric infections.
has issue date	2019-07-30(xsd:dateTime)
bibo:doi	10.1111/lam.13197
bibo:pmid	31278766
has license	no-cc
sha1sum (hex)	508dd51b385f006ef2f6f2fb81f93c2cf4cb5fcc
schema:url	https://doi.org/10.1111/lam.13197
resource representing a document's title	A heterologous ‘prime‐boost’ anti‐PEDV immunization for pregnant sows protects neonatal piglets through lactogenic immunity against PEDV
has PubMed Central identifier	PMC7165963
has PubMed identifier	31278766
schema:publication	Lett Appl Microbiol
resource representing a document's body	covid:508dd51b385f006ef2f6f2fb81f93c2cf4cb5fcc#body_text
is schema:about of	named entity 'prime-boost' named entity 'immunity' named entity 'ENTERITIS' named entity 'MICROSPHERES' named entity 'INDUSTRY' »more»

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