About: A collection of designed peptides to target SARS-Cov-2 – ACE2 interaction: PepI-Covid19 database

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: A collection of designed peptides to target SARS-Cov-2 – ACE2 interaction: PepI-Covid19 database Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A collection of designed peptides to target SARS-Cov-2 – ACE2 interaction: PepI-Covid19 database
Creator	Oliva, Baldo Fernandez-Fuentes, Narcis Molina, Ruben
source	BioRxiv
abstract	The angiotensin-converting enzyme 2 is the cellular receptor used by SARS coronavirus SARS-CoV and SARS-CoV-2 to enter the cell. Both coronavirus use the receptor-binding domain (RBD) of their viral spike protein to interact with ACE2. The structural basis of these interactions are already known, forming a dimer of ACE2 with a trimer of the spike protein, opening the door to target them to prevent the infection. Here we present PepI-Cov19 database, a repository of peptides designed to target the interaction between the RDB of SARS-CoV-2 and ACE2 as well as the dimerization of ACE2 monomers. The peptides were modelled using our method PiPreD that uses native elements of the interaction between the targeted protein and cognate partner that are subsequently included in the designed peptides. These peptides recapitulate stretches of residues present in the native interface plus novel and highly diverse conformations that preserve the key interactions on the interface. PepI-Covid19 database provides an easy and convenient access to this wealth of information to the scientific community with the view of maximizing its potential impact in the development of novel therapeutic agents.
has issue date	2020-04-29(xsd:dateTime)
bibo:doi	10.1101/2020.04.28.051789
has license	biorxiv
sha1sum (hex)	4ff7258d5725cdcb74963fb6a5d686c49ba86b31
schema:url	https://doi.org/10.1101/2020.04.28.051789
resource representing a document's title	A collection of designed peptides to target SARS-Cov-2 – ACE2 interaction: PepI-Covid19 database
schema:publication	bioRxiv
resource representing a document's body	covid:4ff7258d5725cdcb74963fb6a5d686c49ba86b31#body_text
is schema:about of	named entity 'ACE2' named entity 'peptides' named entity 'PRESENT' named entity 'NATIVE' named entity 'FORMING' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software