About: In Silico design and characterization of multi-epitopes vaccine for SARS-CoV2 from its spike proteins

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	In Silico design and characterization of multi-epitopes vaccine for SARS-CoV2 from its spike proteins
Creator	Kathwate, Gunderao
source	BioRxiv
abstract	COVID 19 is disease caused by novel corona virus, SARS-CoV2 originated in China most probably of Bat origin. Till date, no specific vaccine or drug has been discovered to tackle the infections caused by SARS-CoV2. In response to this pandemic, we utilized bioinformatics knowledge to develop efficient vaccine candidate against SARS-CoV2. Designed vaccine was rich in effective BCR and TCR epitopes screened from the sequence of S-protein of SARS-CoV2. Predicted BCR and TCR epitopes were antigenic in nature non-toxic and probably non-allergen. Modelled and refined tertiary structure was predicted as valid for further use. Protein-Protein interaction prediction of TLR2/4 and designed vaccine indicates promising binding. Designed multiepitope vaccine has induced cell mediated and humoral immunity along with increased interferon gamma response. Macrophages and dendritic cells were also found increased over the vaccine exposure. In silico codon optimization and cloning in expression vector indicates that vaccine can be efficiently expressed in E. coli. In conclusion, predicted vaccine is a good antigen, probable no allergen and has potential to induce cellular and humoral immunity.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.1101/2020.06.03.131755
has license	biorxiv
sha1sum (hex)	4f3fbe664b227e47c34147f96637b19635af1e48
schema:url	https://doi.org/10.1101/2020.06.03.131755
resource representing a document's title	In Silico design and characterization of multi-epitopes vaccine for SARS-CoV2 from its spike proteins
schema:publication	bioRxiv
resource representing a document's body	covid:4f3fbe664b227e47c34147f96637b19635af1e48#body_text
is schema:about of	named entity 'develop' named entity 'corona virus' named entity 'tertiary structure' named entity 'proteins' named entity 'USE' »more»

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