About: Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target

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About: Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target
Creator	Zhu, Yan Wang, Tao Rao, Zihe Yang, Haitao Zhang, Ying »more»
source	BioRxiv
abstract	A novel coronavirus (2019-nCoV) outbreak has caused a global pandemic resulting in tens of thousands of infections and thousands of deaths worldwide. The RNA-dependent RNA polymerase (RdRp, also named nsp12), which catalyzes the synthesis of viral RNA, is a key component of coronaviral replication/transcription machinery and appears to be a primary target for the antiviral drug, remdesivir. Here we report the cryo-EM structure of 2019-nCoV full-length nsp12 in complex with cofactors nsp7 and nsp8 at a resolution of 2.9-Å. Additional to the conserved architecture of the polymerase core of the viral polymerase family and a nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain featured in coronaviral RdRp, nsp12 possesses a newly identified β-hairpin domain at its N-terminal. Key residues for viral replication and transcription are observed. A comparative analysis to show how remdesivir binds to this polymerase is also provided. This structure provides insight into the central component of coronaviral replication/transcription machinery and sheds light on the design of new antiviral therapeutics targeting viral RdRp. One Sentence Summary Structure of 2019-nCov RNA polymerase.
has issue date	2020-04-09(xsd:dateTime)
bibo:doi	10.1101/2020.03.16.993386
has license	biorxiv
sha1sum (hex)	4dfb8b2c6c9eaba1010c26c5ac2e15e47c6a7fbf
schema:url	https://doi.org/10.1101/2020.03.16.993386
resource representing a document's title	Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target
schema:publication	bioRxiv
resource representing a document's body	covid:4dfb8b2c6c9eaba1010c26c5ac2e15e47c6a7fbf#body_text
is schema:about of	named entity 'insight' named entity 'machinery' named entity 'polymerase' named entity 'domain' named entity 'identified' »more»

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