About: Fecal viral shedding in COVID-19 patients: clinical significance, viral load dynamics and survival analysis

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About: Fecal viral shedding in COVID-19 patients: clinical significance, viral load dynamics and survival analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Fecal viral shedding in COVID-19 patients: clinical significance, viral load dynamics and survival analysis
Creator	Guo, Lei Wang, Xiaoming Yao, Hao Com, Xia_Xiao_Dong@hotmail Wang, Lingya »more»
source	Elsevier
abstract	Background To investigate the clinical significance, viral shedding duration and viral load dynamics of positive fecal SARS-CoV-2 signals in COVID-19. Methods COVID-19 patients were included. SARS-CoV-2 RNA was tested in stool and respiratory specimens until two sequential negative results were obtained. Clinical, laboratory and imaging data were recorded. Results Of the 69 COVID-19 patients, 20 (28.99%) had positive fecal viral tests who were younger, had lower C-reactive protein (CRP) and fibrinogen (FIB) levels on admission (all P < 0.05), and showed more improvement and less progression on chest CT during recovery. The median duration of positive viral signals was significantly longer in stool samples than in respiratory samples (P < 0.05). In spite of the negative oropharyngeal swabs, eleven patients were tested positive for viral RNA in stool specimens, with their fecal SARS-CoV-2 RNA Ct values reaching 25-27. 6 of these 11 patients' Ct (cycle threshold) values rebounded. Conclusion SARS-CoV-2 RNA in stool specimens was associated with a milder condition and better recovery of chest CT results while the median duration of SARS-CoV-2 RNA persistence was significantly longer in fecal samples than in oropharyngeal swabs. The fecal viral load easily reached a high level and rebounded even though respiratory signals became negative.
has issue date	2020-08-28(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2020.198147
has license	els-covid
sha1sum (hex)	4cfde5b4597b57892a4b3b11e12644ac8c586fb7
schema:url	https://doi.org/10.1016/j.virusres.2020.198147
resource representing a document's title	Fecal viral shedding in COVID-19 patients: clinical significance, viral load dynamics and survival analysis
resource representing a document's body	covid:4cfde5b4597b57892a4b3b11e12644ac8c586fb7#body_text
is schema:about of	named entity 'investigate' named entity 'oropharyngeal' named entity 'radiological' named entity 'fecal' named entity 'Abstract' »more»

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