About: Strategies to develop antivirals against enterovirus 71

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Strategies to develop antivirals against enterovirus 71 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Strategies to develop antivirals against enterovirus 71
Creator	Kuo, Rei-Lin Shih, Shin-Ru
source	Medline; PMC
abstract	Enterovirus 71 (EV71) is an important human pathogen which may cause severe neurological complications and death in children. The virus caused several outbreaks in the Asia-Pacific region during the past two decades and has been considered a significant public health problem in the post-poliovirus eradication era. Unlike poliovirus, there is no effective vaccine or approved antivirals against EV71. To explore anti-EV71 agents therefore is of vital importance. Several strategies have been employed to develop antivirals based on the molecular characteristics of the virus. Among these, some small molecules that were developed against human rhinoviruses and poliovirus are under evaluation. In this review, we discuss the recent development of such small molecules against EV71, known drug resistance and possible solutions to it, and animal models for evaluating the efficacy of these antivirals. Although further investigation is required for clinical applications of the existing candidates, the molecular mechanisms revealed for the inhibition of EV71 replication can be used for designing new molecules against this virus in the future.
has issue date	2013-01-22(xsd:dateTime)
bibo:doi	10.1186/1743-422x-10-28
bibo:pmid	23339605
has license	cc-by
sha1sum (hex)	4cb55c99b99ef1944a0b43b342a8bc9eda6ae227
schema:url	https://doi.org/10.1186/1743-422x-10-28
resource representing a document's title	Strategies to develop antivirals against enterovirus 71
has PubMed Central identifier	PMC3614426
has PubMed identifier	23339605
schema:publication	Virol J
resource representing a document's body	covid:4cb55c99b99ef1944a0b43b342a8bc9eda6ae227#body_text
is schema:about of	named entity 'ANTIVIRALS' named entity 'effective' named entity 'antivirals' named entity 'Strategies' named entity 'STRATEGIES' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software