About: Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Type I and III interferons disrupt lung epithelial repair during recovery from viral infection
Creator	Crotta, S Gad, H Hartmann, R Llorian, M Major, J »more»
source	BioRxiv
abstract	Excessive cytokine signalling frequently exacerbates lung tissue damage during respiratory viral infection. Type I and III interferons (IFN-α/β and IFN-λ) are host-produced antiviral cytokines and currently considered as COVID-19 therapy. Prolonged IFN-α/β responses can lead to harmful proinflammatory effects, whereas IFN-λ mainly signals in epithelia, inducing localised antiviral immunity. Here we show that IFN signalling interferes with lung repair during influenza recovery, with IFN-λ driving these effects most potently. IFN-induced p53 directly reduces epithelial proliferation and differentiation, increasing disease severity and susceptibility to bacterial superinfections. Hence, excessive or prolonged IFN-production aggravates viral infection by impairing lung epithelial regeneration. Therefore, timing and duration are critical parameters of endogenous IFN action, and should be considered carefully for IFN therapeutic strategies against viral infections like influenza and COVID-19. One Sentence Summary A novel IFN-mediated mechanism of immunopathology during respiratory virus infection by interference with lung tissue repair.
has issue date	2020-05-05(xsd:dateTime)
bibo:doi	10.1101/2020.05.05.078360
has license	biorxiv
sha1sum (hex)	4bf32090f5b2de486014d96a5ef21f2a0aabc376
schema:url	https://doi.org/10.1101/2020.05.05.078360
resource representing a document's title	Type I and III interferons disrupt lung epithelial repair during recovery from viral infection
schema:publication	bioRxiv
resource representing a document's body	covid:4bf32090f5b2de486014d96a5ef21f2a0aabc376#body_text
is schema:about of	named entity 'responses' named entity 'influenza' named entity 'epithelia' named entity 'proinflammatory' named entity 'differentiation' »more»

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