About: A simple laboratory parameter facilitates early identification of COVID-19 patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A simple laboratory parameter facilitates early identification of COVID-19 patients
Creator	Wang, Lin Wang, Zheng Chen, Fenghua Ding, Xiuli Geng, Zhi »more»
source	MedRxiv
abstract	The total number of COVID-19 patients since the outbreak of this infection in Wuhan, China has reached 40000 and are still growing. To facilitate triage or identification of the large number of COVID-19 patients from other patients with similar symptoms in designated fever clinics, we set to identify a practical marker that could be conveniently utilized by first-line health-care workers in clinics. To do so, we performed a case-control study by analyzing clinical and laboratory findings between PCR-confirmed SARS-CoV-2 positive patients (n=52) and SARS-CoV-2 negative patients (n=53). The patients in two cohorts all had similar symptoms, mainly fever and respiratory symptoms. The rates of patients with leukocyte counts (normal or decreased number) or lymphopenia (two parameters suggested by current National and WHO COVID-19 guidelines) had no differences between these two cohorts, while the rate of eosinopenia (decreased number of eosinophils) in SARS-CoV-2 positive patients (79%) was much higher than that in SARS-CoV-2 negative patients (36%). When the symptoms were combined with eosinopenia, this combination led to a diagnosis sensitivity and specificity of 79% and 64%, respectively, much higher than 48% and 53% when symptoms were combined with leukocyte counts (normal or decreased number) and/ or lymphopenia. Thus, our analysis reveals that eosinopenia may be a potentially more reliable laboratory predictor for SARS-CoV-2 infection than leukocyte counts and lymphopenia recommended by the current guidelines.
has issue date	2020-02-17(xsd:dateTime)
bibo:doi	10.1101/2020.02.13.20022830
has license	medrxiv
sha1sum (hex)	47b07518dc0f608e53198bb5f8a95caa1c164fe5
schema:url	https://doi.org/10.1101/2020.02.13.20022830
resource representing a document's title	A simple laboratory parameter facilitates early identification of COVID-19 patients
resource representing a document's body	covid:47b07518dc0f608e53198bb5f8a95caa1c164fe5#body_text
is schema:about of	named entity 'EARLY IDENTIFICATION' named entity 'PARAMETER' named entity 'LABORATORY' named entity 'COVID-19' named entity 'SIMPLE' »more»

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