About: Bid cleavage, cytochrome c release and caspase activation in canine coronavirus-induced apoptosis

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About: Bid cleavage, cytochrome c release and caspase activation in canine coronavirus-induced apoptosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Bid cleavage, cytochrome c release and caspase activation in canine coronavirus-induced apoptosis
Creator	Decaro, Nicola De Martino, Luisa Fiorito, Filomena Iovane, Valentina Montagnaro, Serena »more»
source	Elsevier; Medline; PMC
abstract	A previous study demonstrated that infection of a canine fibrosarcoma cell line (A-72 cells) by canine coronavirus (CCoV) resulted in apoptosis (Ruggieri et al., 2007). In this study, we investigated the cell death processes during infection and the underlying mechanisms. We found that CCoV-II triggers apoptosis in A-72 cells by activating initiator (caspase-8 and -9) and executioner (caspase-3 and -6) caspases. The proteolytic cleavage of poly(ADP-ribose) polymerases (PARPs) confirmed the activation of executioner caspases. Furthermore, CCoV-II infection resulted in truncated bid (tbid) translocation from the cytosolic to the mitochondrial fraction, the cytochrome c release from mitochondria, and alterations in the pro- and anti-apoptotic proteins of bcl-2 family. Our data indicated that, in this experimental model, both intrinsic and extrinsic pathways are involved. In addition, we demonstrated that the inhibition of apoptosis by caspase inhibitors did not affect CCoV replication, suggesting that apoptosis does not play a role in facilitating viral release.
has issue date	2010-02-24(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2009.09.001
bibo:pmid	19781871
has license	no-cc
sha1sum (hex)	4642bf94259fd9ddf23595ffda50925223aeca71
schema:url	https://doi.org/10.1016/j.vetmic.2009.09.001
resource representing a document's title	Bid cleavage, cytochrome c release and caspase activation in canine coronavirus-induced apoptosis
has PubMed Central identifier	PMC7117139
has PubMed identifier	19781871
schema:publication	Vet Microbiol
resource representing a document's body	covid:4642bf94259fd9ddf23595ffda50925223aeca71#body_text
is schema:about of	named entity 'INDUCED' named entity 'CANINE CORONAVIRUS' named entity 'caspase' named entity 'Bid' named entity 'BID' »more»

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