About: Mutational spectra of SARS-CoV-2 orf1ab polyprotein and Signature mutations in the United States of America

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About: Mutational spectra of SARS-CoV-2 orf1ab polyprotein and Signature mutations in the United States of America Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Mutational spectra of SARS-CoV-2 orf1ab polyprotein and Signature mutations in the United States of America
Creator	Banerjee, Shuvam Bhattacharjee, Pritha Kousik, ; Mondal, Kr Seal, Sohan »more»
source	BioRxiv
abstract	Pandemic COVID-19 outbreak has been caused due to SARS-COV2 pathogen, resulting millions of infection and death worldwide, USA being on top at the present moment. The long, complex orf1ab polyproteins of SARS-COV2 play an important role in viral RNA synthesis. To assess the impact of mutations in this important domain, we analyzed 1134 complete protein sequences of orf1ab polyprotein from NCBI Virus database from affected patients across various states of USA from December 2019 to 25th April, 2020. Multiple sequence alignment using Clustal Omega followed by statistical significance was calculated. Four significant mutations T265I (nsp 2), P4715L (nsp 12) and P5828L and Y5865C (both at nsp 13) were identified in important non-structural proteins, which function either as replicase or helicase. A comparative analysis shows 265T>I, 5828P>L and 5865Y>C are unique to USA and not reported from Europe or Asia; while one, 4715P>L is predominant in both Europe and USA. Mutational changes in amino acids are predicted to alter structure and function of corresponding proteins, thereby it is imperative to consider the mutational spectra while designing new antiviral therapeutics targeting viral orf1ab.
has issue date	2020-05-01(xsd:dateTime)
bibo:doi	10.1101/2020.05.01.071654
has license	biorxiv
sha1sum (hex)	45a05c51c58226c247999d539127ef8147754b01
schema:url	https://doi.org/10.1101/2020.05.01.071654
resource representing a document's title	Mutational spectra of SARS-CoV-2 orf1ab polyprotein and Signature mutations in the United States of America
schema:publication	bioRxiv
resource representing a document's body	covid:45a05c51c58226c247999d539127ef8147754b01#body_text
is schema:about of	named entity 'database' named entity 'USA' named entity 'mutations' named entity 'polyprotein' named entity 'Clustal' »more»

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