About: Bioactive pyrrole-based compounds with target selectivity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Bioactive pyrrole-based compounds with target selectivity
Creator	Spanò, Virginia Barraja, Paola Holl, Ralph Li, Giovanna Montalbano, Alessandra »more»
source	Elsevier
abstract	The discovery of novel synthetic compounds with drug-like properties is an ongoing challenge in medicinal chemistry. Natural products have inspired the synthesis of compounds for pharmaceutical application, most of which are based on N-heterocyclic motifs. Among these, the pyrrole ring is one of the most explored heterocycles in drug discovery programs for several therapeutic areas, confirmed by the high number of pyrrole-based drugs reaching the market. In the present review, we focused on pyrrole and its hetero-fused derivatives with anticancer, antimicrobial, and antiviral activities, reported in the literature between 2015 and 2019, for which a specific target was identified, being responsible for their biological activity. It emerges that the powerful pharmaceutical and pharmacological features provided by the pyrrole nucleus as pharmacophore unit of many drugs are still recognized by medicinal chemists.
has issue date	2020-08-29(xsd:dateTime)
bibo:doi	10.1016/j.ejmech.2020.112783
has license	els-covid
sha1sum (hex)	450f029aeb9ee3d7cb0b2b6e6ad1e3f017dcf9c9
schema:url	https://doi.org/10.1016/j.ejmech.2020.112783
resource representing a document's title	Bioactive pyrrole-based compounds with target selectivity
resource representing a document's body	covid:450f029aeb9ee3d7cb0b2b6e6ad1e3f017dcf9c9#body_text
is schema:about of	named entity 'BASED' named entity 'European Journal of Medicinal Chemistry' named entity 'pyrrole' named entity 'pyrrole' named entity 'leukemic' »more»

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