About: Be aware of acute kidney injury in critically ill children with COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Be aware of acute kidney injury in critically ill children with COVID-19
Creator	Peng, Xuehua Shao, Jianbo Wang, Xiaowen Xiao, Han Qi, Chang »more»
source	Medline; PMC
abstract	BACKGROUND: Acute kidney injury (AKI) is a common complication of critically ill adult patients with COVID-19. However, currently, no studies investigate kidney impairment in children with COVID-19. We investigated incidence and treatment of AKI in pediatric patients with COVID-19 in Wuhan Children’s Hospital during the early stages of the COVID-19 pandemic and discuss possible mechanisms of AKI related to SARS-CoV-2 infection. METHODS: By extracting data from electronic medical records, we conducted a retrospective observational study of kidney involvement in confirmed pediatric COVID-19 cases in Wuhan Children’s Hospital during the coronavirus outbreak, from January 24 to March 20, 2020. Clinical presentations, clinical courses, laboratory findings, and medical interventions are described below. RESULTS: Among 238 confirmed COVID-19 cases, only three were critically ill and needed intensive care unit (ICU) admission. All three developed AKI, but AKI was not detected in any non-critically ill patients outside the ICU. Two of the three patients with AKI had prodromal gastrointestinal symptoms. Significantly elevated interleukin-6 (IL-6) levels and complement activation were observed in these patients with AKI. The three patients with AKI were treated with plasma exchange (PE) and continuous kidney replacement therapy (CKRT), resulting in one complete recovery, one partial recovery, and one mortality due to critical illness. CONCLUSIONS: Critically ill children with COVID-19 may develop AKI, especially following prodromal gastrointestinal symptoms. An inflammatory storm and complement-mediated injury may underlie AKI development in children with COVID-19. Our study supports implantation of PE and CKRT in management of critically ill patients with AKI.
has issue date	2020-08-26(xsd:dateTime)
bibo:doi	10.1007/s00467-020-04715-z
bibo:pmid	32844290
has license	no-cc
sha1sum (hex)	40cfe27f65cdabe16aa29796c2063e3a1f02f15a
schema:url	https://doi.org/10.1007/s00467-020-04715-z
resource representing a document's title	Be aware of acute kidney injury in critically ill children with COVID-19
has PubMed Central identifier	PMC7447530
has PubMed identifier	32844290
schema:publication	Pediatr Nephrol
resource representing a document's body	covid:40cfe27f65cdabe16aa29796c2063e3a1f02f15a#body_text
is schema:about of	named entity 'observational study' named entity 'AKI' named entity 'common' named entity 'DISCUSS' named entity 'STORM' »more»

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