About: Nonhuman primate species as models of human bacterial sepsis

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Nonhuman primate species as models of human bacterial sepsis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Nonhuman primate species as models of human bacterial sepsis
Creator	Kraft, Bryan Chen, Lingye Welty-Wolf, Karen
source	PMC
abstract	Sepsis involves a disordered host response to systemic infection leading to high morbidity and mortality. Despite intense research, targeted sepsis therapies beyond antibiotics have remained elusive. The cornerstone of sepsis research is the development of animal models to mimic human bacterial infections and test novel pharmacologic targets. Nonhuman primates (NHPs) have served as an attractive, but expensive, animal to model human bacterial infections due to their nearly identical cardiopulmonary anatomy and physiology, as well as host response to infection. Several NHP species have provided substantial insight into sepsis-mediated inflammation, endothelial dysfunction, acute lung injury, and multi-organ failure. The use of NHPs has usually focused on translating therapies from early preclinical models to human clinical trials. However, despite successful sepsis interventions in NHP models, there are still no FDA-approved sepsis therapies. This review highlights major NHP models of bacterial sepsis and their relevance to clinical medicine.
has issue date	2019-01-14(xsd:dateTime)
bibo:doi	10.1038/s41684-018-0217-2
bibo:pmid	30643274
has license	no-cc
sha1sum (hex)	4041dbdf50df73b5c4dd4f9d11f74c7335c33564
schema:url	https://doi.org/10.1038/s41684-018-0217-2
resource representing a document's title	Nonhuman primate species as models of human bacterial sepsis
has PubMed Central identifier	PMC6613635
has PubMed identifier	30643274
schema:publication	Lab Anim (NY)
resource representing a document's body	covid:4041dbdf50df73b5c4dd4f9d11f74c7335c33564#body_text
is schema:about of	named entity 'neural pathways' named entity 'The' named entity 'susceptible' named entity 'endocrine' named entity 'anti-inflammatory' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software