About: RdRp mutations are associated with SARS-CoV-2 genome evolution

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	RdRp mutations are associated with SARS-CoV-2 genome evolution
Creator	Eskier1, Doğa Karakülah1, Gökhan Oktay1, Yavuz Suner3, Aslı
source	BioRxiv
abstract	COVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of viral genome over time as it spread across the world. An important question that still needs to be answered is whether any of the common mutations affect the viral properties, and therefore the disease characteristics. Therefore, we sought to understand the effects of mutations in RNA-dependent RNA polymerase (RdRp), particularly the common 14408C>T mutation, on mutation rate and viral spread. By focusing on mutations in the slowly evolving M or E genes, we aimed to minimize the effects of selective pressure. Our results indicate that 14408C>T mutation increases the mutation rate, while the third-most common RdRp mutation, 15324C>T, has the opposite effect. It is possible that 14408C>T mutation may have contributed to the dominance of its co-mutations in Europe and elsewhere.
has issue date	2020-05-20(xsd:dateTime)
bibo:doi	10.1101/2020.05.20.104885
has license	biorxiv
sha1sum (hex)	3f439ccbba313098292de9c63daee5a2eb3e9aad
schema:url	https://doi.org/10.1101/2020.05.20.104885
resource representing a document's title	RdRp mutations are associated with SARS-CoV-2 genome evolution
schema:publication	bioRxiv
resource representing a document's body	covid:3f439ccbba313098292de9c63daee5a2eb3e9aad#body_text
is schema:about of	named entity 'COVID-19' named entity 'common' named entity 'polymerase' named entity 'genome evolution' named entity 'evolving' »more»

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