About: Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy
Creator	Goyal, Bhupesh Goyal, Deepti
source	Medline; PMC
abstract	[Image: see text] A new coronavirus (CoV) caused a pandemic named COVID-19, which has become a global health care emergency in the present time. The virus is referred to as SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) and has a genome similar (∼82%) to that of the previously known SARS-CoV (SARS coronavirus). An attractive therapeutic target for CoVs is the main protease (M(pro)) or 3-chymotrypsin-like cysteine protease (3CL(pro)), as this enzyme plays a key role in polyprotein processing and is active in a dimeric form. Further, M(pro) is highly conserved among various CoVs, and a mutation in M(pro) is often lethal to the virus. Thus, drugs targeting the M(pro) enzyme significantly reduce the risk of mutation-mediated drug resistance and display broad-spectrum antiviral activity. The combinatorial design of peptide-based inhibitors targeting the dimerization of SARS-CoV M(pro) represents a potential therapeutic strategy. In this regard, we have compiled the literature reports highlighting the effect of mutations and N-terminal deletion of residues of SARS-CoV M(pro) on its dimerization and, thus, catalytic activity. We believe that the present review will stimulate research in this less explored yet quite significant area. The effect of the COVID-19 epidemic and the possibility of future CoV outbreaks strongly emphasize the urgent need for the design and development of potent antiviral agents against CoV infections.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1021/acscombsci.0c00058
bibo:pmid	32402186
has license	no-cc
sha1sum (hex)	3a7dfaff7af07135c55d7b151bbcc2d2ee3e62a3
schema:url	https://doi.org/10.1021/acscombsci.0c00058
resource representing a document's title	Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy
has PubMed Central identifier	PMC7252589
has PubMed identifier	32402186
schema:publication	ACS Comb Sci
resource representing a document's body	covid:3a7dfaff7af07135c55d7b151bbcc2d2ee3e62a3#body_text
is schema:about of	named entity 'emphasize' named entity 'development' named entity 'severe' named entity 'respiratory' named entity 'potential' »more»

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