About: Low Serum 25-Hydroxyvitamin D Level and Risk of Upper Respiratory Tract Infection in Children and Adolescents

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Low Serum 25-Hydroxyvitamin D Level and Risk of Upper Respiratory Tract Infection in Children and Adolescents
Creator	Loeb, Mark Smieja, Marek Science, Michelle Russell, Margaret Walter, Stephen »more»
source	Medline; PMC
abstract	Background. Vitamin D may be important for immune function. Studies to date have shown an inconsistent association between vitamin D and infection with respiratory viruses. The purpose of this study was to determine if serum 25-hydroxyvitamin D (25(OH)D) was associated with laboratory-confirmed viral respiratory tract infections (RTIs) in children. Methods. Serum 25(OH)D levels were measured at baseline and children from Canadian Hutterite communities were followed prospectively during the respiratory virus season. Nasopharyngeal specimens were obtained if symptoms developed and infections were confirmed using polymerase chain reaction. The association between serum 25(OH)D and time to laboratory-confirmed viral RTI was evaluated using a Cox proportional hazards model. Results. Seven hundred forty-three children aged 3–15 years were followed between 22 December 2008 and 23 June 2009. The median serum 25(OH)D level was 62.0 nmol/L (interquartile range, 51.0–74.0). A total of 229 participants (31%) developed at least 1 laboratory-confirmed viral RTI. Younger age and lower serum 25(OH)D levels were associated with increased risk of viral RTI. Serum 25(OH)D levels <75 nmol/L increased the risk of viral RTI by 50% (hazard ratio [HR], 1.51; 95% confidence interval [CI], 1.10–2.07, P = .011) and levels <50 nmol/L increased the risk by 70% (HR, 1.67; 95% CI, 1.16–2.40, P = .006). Conclusions. Lower serum 25(OH)D levels were associated with increased risk of laboratory-confirmed viral RTI in children from Canadian Hutterite communities. Interventional studies evaluating the role of vitamin D supplementation to reduce the burden of viral RTIs are warranted.
has issue date	2013-05-15(xsd:dateTime)
bibo:doi	10.1093/cid/cit289
bibo:pmid	23677871
has license	bronze-oa
sha1sum (hex)	3a2b97873e8189db118a3604c9d52b5cc33f5ace
schema:url	https://doi.org/10.1093/cid/cit289
resource representing a document's title	Low Serum 25-Hydroxyvitamin D Level and Risk of Upper Respiratory Tract Infection in Children and Adolescents
has PubMed Central identifier	PMC3888147
has PubMed identifier	23677871
schema:publication	Clinical Infectious Diseases
resource representing a document's body	covid:3a2b97873e8189db118a3604c9d52b5cc33f5ace#body_text
is schema:about of	named entity 'LOW' named entity 'UPPER RESPIRATORY TRACT INFECTION' named entity '25-HYDROXYVITAMIN D LEVEL' named entity 'LABORATORY' named entity 'VITAMIN D' »more»

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