About: Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): Identification of neutralizing and antibodies reactive to S, N, M and E viral proteins

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About: Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): Identification of neutralizing and antibodies reactive to S, N, M and E viral proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): Identification of neutralizing and antibodies reactive to S, N, M and E viral proteins
Creator	Harcourt, Jennifer Haynes, Lia Miao, Congrong Tamin, Azaibi Rollin, Pierre »more»
source	Elsevier; Medline; PMC
abstract	Monoclonal antibodies (Mabs) against the Urbani strain of the SARS-associated coronavirus (SARS-CoV) were developed and characterized for reactivity to SARS-CoV and SARS-CoV S, N, M, and E proteins using enzyme-linked immunoabsorbent (ELISA), radioimmunoprecipitation, immunofluorescence, Western Blot and microneutralization assays. Twenty-six mAbs were reactive to SARS-CoV by ELISA, and nine were chosen for detailed characterization. Five mAbs reacted against the S protein, two against the M protein, and one each against the N and E proteins. Two of five S protein mAbs neutralized SARS-CoV infection of Vero E6 cells and reacted to an epitope within amino acids 490–510 in the S protein. While two of the three non-neutralizing antibodies recognized at second epitope within amino acids 270–350. The mAbs characterized should prove useful for developing SARS-CoV diagnostic assays and for studying the biology of infection and pathogenesis of disease.
has issue date	2005-05-10(xsd:dateTime)
bibo:doi	10.1016/j.jviromet.2005.03.021
bibo:pmid	15885812
has license	no-cc
sha1sum (hex)	39f84a0a09b6eabcc5426a452c3b7bafddc69f2a
schema:url	https://doi.org/10.1016/j.jviromet.2005.03.021
resource representing a document's title	Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): Identification of neutralizing and antibodies reactive to S, N, M and E viral proteins
has PubMed Central identifier	PMC7112802
has PubMed identifier	15885812
schema:publication	J Virol Methods
resource representing a document's body	covid:39f84a0a09b6eabcc5426a452c3b7bafddc69f2a#body_text
is schema:about of	named entity 'M protein' named entity 'DIAGNOSTIC' named entity 'USING' named entity 'REACTIVE' named entity 'IMMUNOFLUORESCENCE' »more»

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