About: Performance characteristics of the ID NOW COVID-19 assay: A regional health care system experience

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About: Performance characteristics of the ID NOW COVID-19 assay: A regional health care system experience Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Performance characteristics of the ID NOW COVID-19 assay: A regional health care system experience
Creator	Blum, Natalie Casas, Mary Foster, Scott Ghofrani, Mohiedean Kroll, Catherine »more»
source	MedRxiv
abstract	Objectives: We compared the Abbott ID NOW COVID-19 point-of-care test (POCT) with polymerase chain reaction (PCR)-based methods to assess the claimed sensitivity and specificity of POCT and to optimize test utilization in our regional health care system. Methods: Assuming PCR to be the gold standard, we used a convenience sampling of mostly symptomatic COVID-19 suspect hospital patients who had already been tested for internal validation and guideline development purposes by both PCR and POCT to calculate the sensitivity and specificity of POCT with Clopper-Pearson 95% confidence intervals (CI). Results: During the study period, 113 paired patient samples met eligibility criteria. The sensitivity of POCT in this population was calculated to be 94.1% [CI 71.31-99.85%] and the specificity was 99.0% [CI 94.33-99.97%]. Conclusions: Based on the lower sensitivity of POCT and the estimated prevalence of COVID-19 in our symptomatic and asymptomatic hospital patients, we recommend a two-pronged testing approach in which COVID-19 suspect patients are tested by the more sensitive PCR, while asymptomatic patients with a low pre-test probability of infection are tested with POCT supplemented by PCR confirmation of positive results. Furthermore, isolation decisions should not be based on POCT results alone.
has issue date	2020-06-05(xsd:dateTime)
bibo:doi	10.1101/2020.06.03.20116327
has license	medrxiv
sha1sum (hex)	398f91654ed79c1a0e63e0c37df868b2bdda1704
schema:url	https://doi.org/10.1101/2020.06.03.20116327
resource representing a document's title	Performance characteristics of the ID NOW COVID-19 assay: A regional health care system experience
resource representing a document's body	covid:398f91654ed79c1a0e63e0c37df868b2bdda1704#body_text
is schema:about of	named entity 'point-of-care test' named entity 'optimize' named entity 'sensitivity' named entity 'polymerase chain reaction' named entity 'health care' »more»

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