About: Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model

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About: Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model
Creator	Coutard, Bruno Piorkowski, Géraldine Touret, Franck Nougairède, Antoine De 3 Lamballerie, Xavier »more»
source	BioRxiv
abstract	Despite no or limited pre-clinical evidence, repurposed drugs are massively evaluated in clinical trials to palliate the lack of antiviral molecules against SARS-CoV-2. Here we used a Syrian hamster model to assess the antiviral efficacy of favipiravir, understand its mechanism of action and determine its pharmacokinetics. When treatment was initiated before or simultaneously to infection, favipiravir had a strong dose effect, leading to dramatic reduction of infectious titers in lungs and clinical alleviation of the disease. Antiviral effect of favipiravir correlated with incorporation of a large number of mutations into viral genomes and decrease of viral infectivity. The antiviral efficacy observed in this study was achieved with plasma drug exposure comparable with those previously found during human clinical trials and was associated with weight losses in animals. Thereby, pharmacokinetic and tolerance studies are required to determine whether similar effects can be safely achieved in humans.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.1101/2020.07.07.191775
has license	biorxiv
sha1sum (hex)	38cd7a8a09785296d9a532f70a9b4ccef16bc408
schema:url	https://doi.org/10.1101/2020.07.07.191775
resource representing a document's title	Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model
schema:publication	bioRxiv
resource representing a document's body	covid:38cd7a8a09785296d9a532f70a9b4ccef16bc408#body_text
is schema:about of	named entity 'large number' named entity 'effects' named entity 'pharmacokinetic' named entity 'mutations' named entity 'hamster' »more»

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