About: Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load

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About: Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load
Creator	Pizzorno, Andrés Terrier, Olivier Mentré, France Malvy, Denis Ke, Ruian »more»
source	MedRxiv; Medline
abstract	We modeled the viral dynamics of 13 untreated patients infected with SARS-CoV-2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than 2 logs, drug efficacy needs to be greater than 80% if treatment is administered after symptom onset; an efficacy of 50% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range of 20-70% efficacy. They may help control virus if administered very early, but may not have a major effect in severe patients.
has issue date	2020-04-07(xsd:dateTime)
bibo:doi	10.1101/2020.04.04.20047886
bibo:pmid	32511641
has license	medrxiv
sha1sum (hex)	3843689b55794bbb8b950d7180899674ddc7e933
schema:url	https://doi.org/10.1101/2020.04.04.20047886
resource representing a document's title	Timing of antiviral treatment initiation is critical to reduce SARS-Cov-2 viral load
has PubMed identifier	32511641
schema:publication	medRxiv : the preprint server for health sciences
resource representing a document's body	covid:3843689b55794bbb8b950d7180899674ddc7e933#body_text
is schema:about of	named entity 'COUNT' covid:arg/3843689b55794bbb8b950d7180899674ddc7e933 named entity 'TEXT' named entity 'VIRAL LOAD' named entity '100%' »more»

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