About: Fine epitope mapping of glycoprotein Gn in Guertu virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Fine epitope mapping of glycoprotein Gn in Guertu virus
Creator	Wang, Chen Xu, Wan-Xiang Zhang, Jingyuan Deng, Fei Ding, Juntao »more»
source	PMC
abstract	Guertu virus (GTV) is a tick-borne phleboviruses (TBPVs) which belongs to the genus Banyangvirus in the family of Phenuiviridae. In vitro and in vivo studies of GTV demonstrated that it was able to infect animal and human cell lines and could cause pathological lesions in mice. Glycoproteins (GP, including Gn and Gc) on the surface of Guertu virus (GTV) could bind to receptors on host cells and induce protective immunity in the host, but knowledge is now lacking on the information of B cell epitopes (BCEs) present on GTV-GP protein. The aim of this study was to identify all BCEs on Gn of the GTV DXM strain using rabbit pAbs against GTV-Gn. Seven fine BCEs and two antigenic peptides (APs) from nine reactive 16mer-peptides were identified, which are E(Gn)1 ((2)PIICEGLTHS(11)), E(Gn)2 ((135)CSQDSGT(141)), E(Gn)3 ((165)IP EDVF(170)), E(Gn)4 ((169)VFQEL K(174)), E(Gn)5 ((187)IDGILFN(193)), E(Gn)6 ((223)QTKWIQ(228)), E(Gn)7 ((237)CHKDGIGPC(245)), AP-8 ((299)GVRVRPKCYGFSRMMA(314)) and AP-9 ((355)CASH FCSSAESGKKNT(370)), of which six of mapped BCEs were recognized by the IgG-positive sheep serum obtained from sheep GTV-infected naturally. Multiple sequence alignments (MSA) based on each mapped BCE motif identified that the most of identified BCEs and APs are highly conserved among 10 SFTSV strains from different countries and lineages that share relatively close evolutionary relationships with GTV. The fine epitope mapping of the GTV-Gn would provide basic data with which to explore the GTV-Gn antigen structure and pathogenic mechanisms, and it could lay the foundation for the design and development of a GTV multi-epitope peptide vaccine and detection antigen.
has issue date	2019-10-16(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0223978
bibo:pmid	31618247
has license	cc-by
sha1sum (hex)	37ce6523b9d7806ed86759bc36b5c6efcfa6dda3
schema:url	https://doi.org/10.1371/journal.pone.0223978
resource representing a document's title	Fine epitope mapping of glycoprotein Gn in Guertu virus
has PubMed Central identifier	PMC6795428
has PubMed identifier	31618247
schema:publication	PLoS One
resource representing a document's body	covid:37ce6523b9d7806ed86759bc36b5c6efcfa6dda3#body_text
is schema:about of	named entity 'conserved' named entity 'epitope mapping' named entity 'DXM' named entity 'sequence' named entity 'basic' »more»

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