About: Assessing required SARS-CoV-2 blanket testing rates for possible control of the outbreak in the epicentre Lusaka province of Zambia with consideration for asymptomatic individuals: a simple mathematical modelling study.

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About: Assessing required SARS-CoV-2 blanket testing rates for possible control of the outbreak in the epicentre Lusaka province of Zambia with consideration for asymptomatic individuals: a simple mathematical modelling study. Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Assessing required SARS-CoV-2 blanket testing rates for possible control of the outbreak in the epicentre Lusaka province of Zambia with consideration for asymptomatic individuals: a simple mathematical modelling study.
Creator	Kikonko, Mervis Munsaka, Sody Simuunza, Martin Sichone, Joseph Sinkala, Musalula
source	MedRxiv
abstract	Abstract. Introduction: The novel Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus - 2 (SARS-CoV-2), in Africa is characterised by a more substantial proportion of asymptomatic (or mildly symptomatic) individuals thought to be playing a role in the spread of the infection. The exact proportion and degree of infectiousness of asymptomatic individuals remains unclear. Studies however indicate that their management is crucial for control of SARS-CoV-2 transmission. Methodology: We developed a simplified deterministic susceptible-exposed-infectious-removed (SEIR) mathematical model to assess the effect of active isolation of SARS-CoV-2 infected but asymptomatic individuals through blanket testing for control of the outbreak in Lusaka Province of Zambia. Here we modelled two scenarios; (1) assuming asymptomatic individuals comprised 70% of all COVID-19 cases and (2) asymptomatic individuals comprised only 50% of the cases. For contrast, the model was assessed first under the assumption that asymptomatic individuals are equally as infectious as symptomatic individuals and then secondly, and more likely, assuming asymptomatic individuals are only half as infectious as symptomatic individuals. Results: For the model assuming 70% asymptomatic cases, a minimum sustained blanket testing rate of [≥] 7911 tests/100000 population was sufficient to control the outbreak if asymptomatic individuals are only half as infectious while if equal infectiousness was assumed then a testing rate of [≥] 10028 tests/ 100000 population would be required. For 50% asymptomatic, minimum blanket testing rates of [≥] 4540 tests/ 100000 population was sufficient to control the outbreak at both assumed levels of infectiousness for asymptomatic individuals relative to symptomatic individuals. Discussion and conclusion: Our model predicts that the current testing rates of {approx} 150/100,000 population are inadequate to control transmission of SARS-Cov-2 in Lusaka. Active isolation of COVID-19 cases including asymptomatic individuals through blanket testing can be used as a possible measure for control of the SARS-Cov-2 transmission in Lusaka, Zambia. Key words: SARS-Cov-2, asymptomatic transmission, deterministic model, blanket testing
has issue date	2020-07-14(xsd:dateTime)
bibo:doi	10.1101/2020.07.12.20152124
has license	medrxiv
sha1sum (hex)	3716b8b32662774d8024641ed9b53a64d976381a
schema:url	https://doi.org/10.1101/2020.07.12.20152124
resource representing a document's title	Assessing required SARS-CoV-2 blanket testing rates for possible control of the outbreak in the epicentre Lusaka province of Zambia with consideration for asymptomatic individuals: a simple mathematical modelling study.
resource representing a document's body	covid:3716b8b32662774d8024641ed9b53a64d976381a#body_text
is schema:about of	named entity 'transmission' named entity 'control' named entity 'SARS-CoV-2' named entity 'consideration' named entity 'SARS-Cov-2' »more»

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