About: Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes
Creator	Levine, Beth Yan, Nan Brugarolas, James Dozmorov, Igor Hasan, Maroof »more»
source	Medline; PMC
abstract	Innate immune sensing of viral nucleic acids triggers type I interferon (IFN) production, which activates interferon-stimulated genes (ISGs) and directs a multifaceted antiviral response. ISGs can also be activated through IFN-independent pathways, although the precise mechanisms remain elusive. Here we found that the cytosolic exonuclease Trex1 regulates the activation of a subset of ISGs independently of IFN. Both Trex1(−/−) mouse and TREX1-mutant human cells express high levels of antiviral genes and are refractory to viral infections. The IFN-independent activation of antiviral genes in Trex1(−/−) cells requires STING, TBK1 and IRF3 and IRF7. We also found that Trex1-deficient cells display expanded lysosomal compartment, altered subcellular localization of the transcription factor EB (TFEB), and reduced mTORC1 activity. Together, our data identify Trex1 as a regulator of lysosomal biogenesis and IFN-independent activation of antiviral genes, and shows dysregulation of lysosomes can elicit innate immune responses.
has issue date	2012-11-18(xsd:dateTime)
bibo:doi	10.1038/ni.2475
bibo:pmid	23160154
has license	no-cc
sha1sum (hex)	35c420fb4598e8d833173d957564539f37162d0d
schema:url	https://doi.org/10.1038/ni.2475
resource representing a document's title	Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes
has PubMed Central identifier	PMC3522772
has PubMed identifier	23160154
schema:publication	Nat Immunol
resource representing a document's body	covid:35c420fb4598e8d833173d957564539f37162d0d#body_text
is schema:about of	named entity 'INDEPENDENT' named entity 'GENES' named entity 'ACTIVATES' named entity 'GENES' named entity 'PRECISE' »more»

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