About: Successful treatment of feline leishmaniosis using a combination of allopurinol and N-methyl-glucamine antimoniate

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About: Successful treatment of feline leishmaniosis using a combination of allopurinol and N-methyl-glucamine antimoniate Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Successful treatment of feline leishmaniosis using a combination of allopurinol and N-methyl-glucamine antimoniate
Creator	Duarte, Ana Tavares, Luís Gomes, Lídia Marques, Cátia Pissarra, Hugo »more»
source	Medline; PMC
abstract	CASE SUMMARY: This work describes the diagnosis and successful treatment of a 2-year-old domestic cat infected with Leishmania species and presenting fever, and ulcerative and nodular skin lesions after being treated for pyodermatitis for 1 year without clinical improvement. After anamnesis the cat was submitted to a complete clinical examination. Blood was collected for determination of haematological and biochemical parameters, detection of feline leukaemia virus (FeLV), feline immunodeficiency virus (FIV), feline coronavirus (FCoV) and Leishmania amastigotes. Fine-needle aspiration puncture from the skin nodules was also performed. After definitive diagnosis the animal was treated and followed up over a 2 year period. The animal tested negative for FIV-specific antibodies, FeLV antigen and feline coronavirus RNA. Leishmania amastigotes in the skin nodules were confirmed by cytology and molecular diagnosis. Treatment was initiated with allopurinol, resulting in a slight clinical improvement. Thus, N-methyl-glucamine antimoniate was added and administered for 30 days, with complete closure of the ulcerative lesions in the hindlimbs requiring a surgical approach. Close monitoring of the patient in the following 24 months indicated that combined therapy was safe and clinical cure was achieved without further relapses or side effects. RELEVANCE AND NOVEL INFORMATION: Considering the increasing number of feline leishmaniosis cases and the inconsistent results of most therapeutic protocols described in the literature, the use of new approaches, especially in refractory cases, is essential. Although the use of allopurinol and N-methyl-glucamine antimoniate is off-label in cats, in this case the combination treatment was followed by an extensive analytical monitoring, supporting their safety and effectiveness.
has issue date	2016-02-10(xsd:dateTime)
bibo:doi	10.1177/2055116916630002
bibo:pmid	28491411
has license	cc-by-nc
sha1sum (hex)	357af8bb837fb3521423284fa624316d0965bfa3
schema:url	https://doi.org/10.1177/2055116916630002
resource representing a document's title	Successful treatment of feline leishmaniosis using a combination of allopurinol and N-methyl-glucamine antimoniate
has PubMed Central identifier	PMC5362848
has PubMed identifier	28491411
schema:publication	JFMS Open Rep
resource representing a document's body	covid:357af8bb837fb3521423284fa624316d0965bfa3#body_text
is schema:about of	named entity 'definitive' named entity 'hindlimbs' named entity 'patient' named entity 'combined' named entity 'allopurinol' »more»

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