About: Hepatitis C Virus and Cellular Stress Response: Implications to Molecular Pathogenesis of Liver Diseases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Hepatitis C Virus and Cellular Stress Response: Implications to Molecular Pathogenesis of Liver Diseases
Creator	Ke, Po-Yuan Chen, -L
source	Medline; PMC
abstract	Infection with hepatitis C virus (HCV) is a leading risk factor for chronic liver disease progression, including steatosis, cirrhosis, and hepatocellular carcinoma. With approximately 3% of the human population infected worldwide, HCV infection remains a global public health challenge. The efficacy of current therapy is still limited in many patients infected with HCV, thus a greater understanding of pathogenesis in HCV infection is desperately needed. Emerging lines of evidence indicate that HCV triggers a wide range of cellular stress responses, including cell cycle arrest, apoptosis, endoplasmic reticulum (ER) stress/unfolded protein response (UPR), and autophagy. Also, recent studies suggest that these HCV-induced cellular responses may contribute to chronic liver diseases by modulating cell proliferation, altering lipid metabolism, and potentiating oncogenic pathways. However, the molecular mechanism underlying HCV infection in the pathogenesis of chronic liver diseases still remains to be determined. Here, we review the known stress response activation in HCV infection in vitro and in vivo, and also explore the possible relationship of a variety of cellular responses with the pathogenicity of HCV-associated diseases. Comprehensive knowledge of HCV-mediated disease progression shall shed new insights into the discovery of novel therapeutic targets and the development of new intervention strategy.
has issue date	2012-10-19(xsd:dateTime)
bibo:doi	10.3390/v4102251
bibo:pmid	23202463
has license	cc-by
sha1sum (hex)	33bee45e93ec92d0813e39a07e158605af679215
schema:url	https://doi.org/10.3390/v4102251
resource representing a document's title	Hepatitis C Virus and Cellular Stress Response: Implications to Molecular Pathogenesis of Liver Diseases
has PubMed Central identifier	PMC3497051
has PubMed identifier	23202463
schema:publication	Viruses
resource representing a document's body	covid:33bee45e93ec92d0813e39a07e158605af679215#body_text
is schema:about of	named entity 'MOLECULAR' named entity 'KNOWN' named entity 'HEPATOCELLULAR CARCINOMA' named entity 'IN VIVO' named entity 'ASSOCIATED' »more»

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