About: Recurrence of SARS-CoV-2 PCR positivity in COVID-19 patients: a single center experience and potential implications

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Recurrence of SARS-CoV-2 PCR positivity in COVID-19 patients: a single center experience and potential implications
Creator	Qu, Jiuxin Li, Zhen Li, Jinxiu Liu, Lei Liu, Yingxia »more»
source	MedRxiv
abstract	IMPORTANCE How to appropriately care for patients who become PCR-negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still not known. Patients who have recovered from coronavirus disease 2019 (COVID-19) could profoundly impact the health care system if a subset were to be PCR-positive again with reactivated SARS-CoV-2. OBJECTIVE To characterize a single center COVID-19 cohort with and without recurrence of PCR positivity, and develop an algorithm to identify patients at high risk of retest positivity after discharge to inform health care policy and case management decision-making. DESIGN, SETTING, AND PARTICIPANTS A cohort of 414 patients with confirmed SARS-CoV-2 infection, at The Second Affiliated Hospital of Southern University of Science and Technology in Shenzhen, China from January 11 to April 23, 2020. EXPOSURES Polymerase chain reaction (PCR) and IgM-IgG antibody confirmed SARS-CoV-2 infection. MAIN OUTCOMES AND MEASURES Univariable and multivariable statistical analysis of the clinical, laboratory, radiologic image, medical treatment, and clinical course of admission/quarantine/readmission data to develop an algorithm to predict patients at risk of recurrence of PCR positivity. RESULTS 16.7% (95CI: 13.0%-20.3%) patients retest PCR positive 1 to 3 times after discharge, despite being in strict quarantine. The driving factors in the recurrence prediction model included: age, BMI; lowest levels of the blood laboratory tests during hospitalization for cholinesterase, fibrinogen, albumin, prealbumin, calcium, eGFR, creatinine; highest levels of the blood laboratory tests during hospitalization for total bilirubin, lactate dehydrogenase, alkaline phosphatase; the first test results during hospitalization for partial pressure of oxygen, white blood cell and lymphocyte counts, blood procalcitonin; and the first test episodic Ct value and the lowest Ct value of the nasopharyngeal swab RT PCR results. Area under the ROC curve is 0.786. CONCLUSIONS AND RELEVANCE This case series provides clinical characteristics of COVID-19 patients with recurrent PCR positivity, despite strict quarantine, at a 16.7% rate. Use of a recurrence prediction algorithm may identify patients at high risk of PCR retest positivity of SARS-CoV-2 and help modify COVID-19 case management and health policy approaches.
has issue date	2020-05-10(xsd:dateTime)
bibo:doi	10.1101/2020.05.06.20089573
has license	medrxiv
sha1sum (hex)	3074b51f9b6134655dffc154c8b99442047337d7
schema:url	https://doi.org/10.1101/2020.05.06.20089573
resource representing a document's title	Recurrence of SARS-CoV-2 PCR positivity in COVID-19 patients: a single center experience and potential implications
resource representing a document's body	covid:3074b51f9b6134655dffc154c8b99442047337d7#body_text
is schema:about of	named entity 'CC-BY 4.0 International license' named entity 'procalcitonin' named entity 'SARS-CoV-2' named entity 'Shenzhen' named entity 'WHO' »more»

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