About: Full-Genome Deep Sequencing and Phylogenetic Analysis of Novel Human Betacoronavirus

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About: Full-Genome Deep Sequencing and Phylogenetic Analysis of Novel Human Betacoronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Full-Genome Deep Sequencing and Phylogenetic Analysis of Novel Human Betacoronavirus
Creator	Kong, Hong Rambaut, ); University, The
source	Medline; PMC
abstract	A novel betacoronavirus associated with lethal respiratory and renal complications was recently identified in patients from several countries in the Middle East. We report the deep genome sequencing of the virus directly from a patient’s sputum sample. Our high-throughput sequencing yielded a substantial depth of genome sequence assembly and showed the minority viral variants in the specimen. Detailed phylogenetic analysis of the virus genome (England/Qatar/2012) revealed its close relationship to European bat coronaviruses circulating among the bat species of the Vespertilionidae family. Molecular clock analysis showed that the 2 human infections of this betacoronavirus in June 2012 (EMC/2012) and September 2012 (England/Qatar/2012) share a common virus ancestor most likely considerably before early 2012, suggesting the human diversity is the result of multiple zoonotic events.
has issue date	2013-05-01(xsd:dateTime)
bibo:doi	10.3201/eid1905.130057
bibo:pmid	23693015
has license	no-cc
sha1sum (hex)	2f56502b1b23bd52dcf3e700ff370667fac055ee
schema:url	https://doi.org/10.3201/eid1905.130057
resource representing a document's title	Full-Genome Deep Sequencing and Phylogenetic Analysis of Novel Human Betacoronavirus
has PubMed Central identifier	PMC3647518
has PubMed identifier	23693015
schema:publication	Emerg Infect Dis
resource representing a document's body	covid:2f56502b1b23bd52dcf3e700ff370667fac055ee#body_text
is schema:about of	named entity 'specimen' named entity 'Betacoronavirus' named entity 'GENOME' named entity 'RECENTLY' named entity '27S' »more»

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