About: Short-Sighted Virus Evolution and a Germline Hypothesis for Chronic Viral Infections

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About: Short-Sighted Virus Evolution and a Germline Hypothesis for Chronic Viral Infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Short-Sighted Virus Evolution and a Germline Hypothesis for Chronic Viral Infections
Creator	Grove, Joe Pybus, Oliver Gardner, Andy Lythgoe, Katrina
source	Elsevier; Medline; PMC
abstract	With extremely short generation times and high mutability, many viruses can rapidly evolve and adapt to changing environments. This ability is generally beneficial to viruses as it allows them to evade host immune responses, evolve new behaviours, and exploit ecological niches. However, natural selection typically generates adaptation in response to the immediate selection pressures that a virus experiences in its current host. Consequently, we argue that some viruses, particularly those characterised by long durations of infection and ongoing replication, may be susceptible to short-sighted evolution, whereby a virus’ adaptation to its current host will be detrimental to its onward transmission within the host population. Here we outline the concept of short-sighted viral evolution and provide examples of how it may negatively impact viral transmission among hosts. We also propose that viruses that are vulnerable to short-sighted evolution may exhibit strategies that minimise its effects. We speculate on the various mechanisms by which this may be achieved, including viral life history strategies that result in low rates of within-host evolution, or the establishment of a ‘germline’ lineage of viruses that avoids short-sighted evolution. These concepts provide a new perspective on the way in which some viruses have been able to establish and maintain global pandemics.
has issue date	2017-04-01(xsd:dateTime)
bibo:doi	10.1016/j.tim.2017.03.003
bibo:pmid	28377208
has license	cc-by
sha1sum (hex)	2e237dc7ffdacf42c76c0671bea72fae2a3ec9e1
schema:url	https://doi.org/10.1016/j.tim.2017.03.003
resource representing a document's title	Short-Sighted Virus Evolution and a Germline Hypothesis for Chronic Viral Infections
has PubMed Central identifier	PMC5405858
has PubMed identifier	28377208
schema:publication	Trends Microbiol
resource representing a document's body	covid:2e237dc7ffdacf42c76c0671bea72fae2a3ec9e1#body_text
is schema:about of	named entity 'extremely' named entity 'changing' named entity 'Hypothesis' named entity 'HYPOTHESIS' named entity 'GERMLINE' »more»

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