About: Food Restriction Differentially Affects mRNAs Encoding the Major Anterior Pituitary Tropic Hormones

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Food Restriction Differentially Affects mRNAs Encoding the Major Anterior Pituitary Tropic Hormones
Creator	Han, Eun-Soo Lu, Deedee Nelson, James
source	PMC
abstract	Chronic food restriction (FR) leads to adaptive cellular changes, some of which retard aging. Moreover, some of these changes occur within weeks after onset of FR. Because neuroendocrine mechanisms may mediate these effects, we measured the effect of FR on the messenger ribonucleicacids (mRNAs) encoding all of the tropic hormones of the anterior pituitary (AP). Slot blot and solution hybridization were conducted on AP ribonucleicacid (RNA) samples obtained at 0500 h (AM) and 1500 h (PM) from 3-month-old male Fischer 344 rats fed ad libitum (AL) or FR (60% of AL calories) since 6 weeks of age. Poly A RNA/μg total RNA was similar in AL and FR rats, indicating that there was no overall effect of FR on mRNA levels. The level of proopiomelanocortin (POMC) mRNA was not reduced by FR when expressed per fig of RNA or as total AP content. By contrast, the total AP content of the mRNAs encoding LHβ, FSHβ TSHβ, GH, and PRL was markedly reduced by FR. When expressed per fig of RNA, however, only GH (AM and PM), FSHβ (AM), TSHbeta; (PM), and PRL (PM) were reduced by FR. These results reveal that FR differentially affects pituitary tropic hormone mRNA levels within weeks after onset of FR, and are consistent with a role for neuroendocrine alterations in the initiation of adaptive cellular responses to FR.
has issue date	1998-09-01(xsd:dateTime)
bibo:doi	10.1093/gerona/53a.5.b322
bibo:pmid	9754129
has license	no-cc
sha1sum (hex)	2da45f268f8ad7dc598551577e895a213a4fbe05
schema:url	https://doi.org/10.1093/gerona/53a.5.b322
resource representing a document's title	Food Restriction Differentially Affects mRNAs Encoding the Major Anterior Pituitary Tropic Hormones
has PubMed Central identifier	PMC7110300
has PubMed identifier	9754129
schema:publication	J Gerontol A Biol Sci Med Sci
resource representing a document's body	covid:2da45f268f8ad7dc598551577e895a213a4fbe05#body_text
is schema:about of	named entity 'mRNA' named entity 'indicating' named entity 'Chronic' named entity 'effects' named entity 'mRNA' »more»

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