About: Metagenomics reshapes the concepts of RNA virus evolution by revealing extensive horizontal virus transfer

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About: Metagenomics reshapes the concepts of RNA virus evolution by revealing extensive horizontal virus transfer Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Metagenomics reshapes the concepts of RNA virus evolution by revealing extensive horizontal virus transfer
Creator	Dolja, Valerian Koonin, Eugene
source	Elsevier; Medline; PMC
abstract	Abstract Virus metagenomics is a young research filed but it has already transformed our understanding of virus diversity and evolution, and illuminated at a new level the connections between virus evolution and the evolution and ecology of the hosts. In this review article, we examine the new picture of the evolution of RNA viruses, the dominant component of the eukaryotic virome, that is emerging from metagenomic data analysis. The major expansion of many groups of RNA viruses through metagenomics allowed the construction of substantially improved phylogenetic trees for the conserved virus genes, primarily, the RNA-dependent RNA polymerases (RdRp). In particular, a new superfamily of widespread, small positive-strand RNA viruses was delineated that unites tombus-like and noda-like viruses. Comparison of the genome architectures of RNA viruses discovered by metagenomics and by traditional methods reveals an extent of gene module shuffling among diverse virus genomes that far exceeds the previous appreciation of this evolutionary phenomenon. Most dramatically, inclusion of the metagenomic data in phylogenetic analyses of the RdRp resulted in the identification of numerous, strongly supported groups that encompass RNA viruses from diverse hosts including different groups of protists, animals and plants. Notwithstanding potential caveats, in particular, incomplete and uneven sampling of eukaryotic taxa, these highly unexpected findings reveal horizontal virus transfer (HVT) between diverse hosts as the central aspect of RNA virus evolution. The vast and diverse virome of invertebrates, particularly nematodes and arthropods, appears to be the reservoir, from which the viromes of plants and vertebrates evolved via multiple HVT events.
has issue date	2018-01-15(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2017.10.020
bibo:pmid	29103997
has license	els-covid
sha1sum (hex)	2a197ed4d48eae056f22353ce06e5702a6261ee6
schema:url	https://doi.org/10.1016/j.virusres.2017.10.020
resource representing a document's title	Metagenomics reshapes the concepts of RNA virus evolution by revealing extensive horizontal virus transfer
has PubMed Central identifier	PMC5801114
has PubMed identifier	29103997
schema:publication	Virus Research
resource representing a document's body	covid:2a197ed4d48eae056f22353ce06e5702a6261ee6#body_text
is schema:about of	named entity 'Virus' named entity 'metagenomics' named entity 'groups' named entity 'analyses' named entity 'transformed' »more»

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