About: What can the ideal gas say about global pandemics? Reinterpreting the basic reproduction number

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	What can the ideal gas say about global pandemics? Reinterpreting the basic reproduction number
Creator	Dickson, Bradley
source	MedRxiv
abstract	Through analysis of the ideal gas, we construct a random walk that on average matches the standard susceptible-infective-removed (SIR) model. We show that the most widely referenced parameter, the 'basic reproduction number' (R0), is fundamentally connected to the relative odds of increasing or decreasing the infectives population. As a consequence, for R0 > 1 the probability that no outbreak occurs is 1/R0. In stark contrast to a deterministic SIR, when R0 = 1.5 the random walk has a 67% chance of avoiding outbreak. Thus, an alternative, probabilistic, interpretation of R0 arises, which provides a novel estimate of the critical population density {gamma}/r without fitting SIR models. We demonstrate that SARS-CoV2 in the United States is consistent with our model and attempt an estimate of {gamma}/r. In doing so, we uncover a significant source of bias in public data reporting. Data are aggregated on political boundaries, which bear no concern for dispersion of population density. We show that this introduces bias in fits and parameter estimates, a concern for understanding fundamental virus parameters and for policy making. Anonymized data at the resolution required for contact tracing would afford access to {gamma}/r without fitting. The random walk SIR developed here highlights the intuition that any epidemic is stochastic and recovers all the key parameter values noted by Kermack and McKendrick in 1927.
has issue date	2020-07-11(xsd:dateTime)
bibo:doi	10.1101/2020.07.09.20150128
has license	medrxiv
sha1sum (hex)	283fcb13e98144f41a8bf319cb8cf9ecda6e357f
schema:url	https://doi.org/10.1101/2020.07.09.20150128
resource representing a document's title	What can the ideal gas say about global pandemics? Reinterpreting the basic reproduction number
resource representing a document's body	covid:283fcb13e98144f41a8bf319cb8cf9ecda6e357f#body_text
is schema:about of	named entity 'virus' named entity 'highlights' named entity 'pandemics' named entity 'matches' named entity 'contact tracing' »more»

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