About: Gap junction internalization and processing in vivo: a 3D immuno-electron microscopy study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Gap junction internalization and processing in vivo: a 3D immuno-electron microscopy study
Creator	Norris, Rachael Terasaki, Mark
source	BioRxiv
abstract	Gap junctions have well-established roles in cell-cell communication by way of forming permeable intercellular channels. Less is understood about their internalization, which forms double membrane vesicles containing cytosol and membranes from another cell, called connexosomes or annular gap junctions. Here, we systematically studied the fate of connexosomes in intact ovarian follicles. High pressure frozen, serial sectioned tissue was immunogold labeled for Connexin 43. Within a volume of electron micrographs, every labeled structure was categorized and counted. Surface area measurements indicate that large connexosomes undergo fission. Subsequent modifications are separation of inner and outer membranes, loss of Cx43 from the outer membrane, and outward budding of the modified membranes. We also documented several clear examples of organelle transfer from one cell to another by gap junction internalization. We discuss how connexosome formation and processing may be a novel means for gap junctions to mediate cell-cell communication.
has issue date	2020-06-30(xsd:dateTime)
bibo:doi	10.1101/2020.06.29.178475
has license	biorxiv
sha1sum (hex)	282edc2ec9336ee56549594a8ec5a22b78c467bc
schema:url	https://doi.org/10.1101/2020.06.29.178475
resource representing a document's title	Gap junction internalization and processing in vivo: a 3D immuno-electron microscopy study
schema:publication	bioRxiv
resource representing a document's body	covid:282edc2ec9336ee56549594a8ec5a22b78c467bc#body_text
is schema:about of	named entity 'annular' named entity 'ELECTRON' named entity 'IMMUNOGOLD' named entity 'HIGH PRESSURE' named entity 'LARGE' »more»

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