About: Binding of the SARS-CoV-2 Spike Protein to Glycans

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About: Binding of the SARS-CoV-2 Spike Protein to Glycans Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Binding of the SARS-CoV-2 Spike Protein to Glycans
Creator	Cui, Sheng Hao, Wei Wang, Xiaoyu Qin, Bo Ma, Bo »more»
source	BioRxiv
abstract	The pandemic of SARS-CoV-2 has caused a high number of deaths in the world. To combat it, it is necessary to develop a better understanding of how the virus infects host cells. Infection normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate (HS) and sialic acid-containing oligosaccharides. In this study, we examined and compared the binding of the subunits and spike (S) proteins of SARS-CoV-2 and SARS-CoV, MERS-CoV to these glycans. Our results revealed that the S proteins and subunits can bind to HS in a sulfation-dependent manner, the length of HS is not a critical factor for the binding, and no binding with sialic acid residues was detected. Overall, this work suggests that HS binding may be a general mechanism for the attachment of these coronaviruses to host cells, and supports the potential importance of HS in infection and in the development of antiviral agents against these viruses.
has issue date	2020-07-02(xsd:dateTime)
bibo:doi	10.1101/2020.05.17.100537
has license	biorxiv
sha1sum (hex)	27df1fc2fa0fab2bd274ee77148eaadcb6b513db
schema:url	https://doi.org/10.1101/2020.05.17.100537
resource representing a document's title	Binding of the SARS-CoV-2 Spike Protein to Glycans
schema:publication	bioRxiv
resource representing a document's body	covid:27df1fc2fa0fab2bd274ee77148eaadcb6b513db#body_text
is schema:about of	named entity 'supports' named entity 'binding' named entity 'subunits' named entity 'CAUSED' named entity 'VIRUSES' »more»

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