About: The potential use of thalidomide in the therapy of graft-versus-host disease—A review of clinical and laboratory information

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About: The potential use of thalidomide in the therapy of graft-versus-host disease—A review of clinical and laboratory information Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The potential use of thalidomide in the therapy of graft-versus-host disease—A review of clinical and laboratory information
Creator	Proctor, Stephen Wood, Philip
source	Elsevier; Medline; PMC
abstract	Abstract This article reviews the historical development of thalidomide as an immunosuppressive agent and the current state of knowledge of thalidomide as an anti-graft-versus-host disease (GVHD) agent. The evidence suggests that metabolites of thalidomide act at an early stage in the antigen recognition-activation pathway of graft T lymphocytes and down regulate normal lymphocyte responses. This effect seems to have beneficial effects in both acute and chronic GVHD, but the optimal mode of use in the clinical setting remains to be determined.
has issue date	1990-12-31(xsd:dateTime)
bibo:doi	10.1016/0145-2126(90)90024-4
bibo:pmid	2189044
has license	els-covid
sha1sum (hex)	278a56f9f269026573a67d60e5dca3eb0a263371
schema:url	https://doi.org/10.1016/0145-2126%2890%2990024-4
resource representing a document's title	The potential use of thalidomide in the therapy of graft-versus-host disease—A review of clinical and laboratory information
has PubMed Central identifier	PMC7133718
has PubMed identifier	2189044
schema:publication	Leukemia Research
resource representing a document's body	covid:278a56f9f269026573a67d60e5dca3eb0a263371#body_text
is schema:about of	named entity 'early' named entity 'acute' named entity 'REVIEW OF' named entity 'REGULATE' named entity 'NORMAL' »more»

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