About: Inhibition of SIRT1 by microRNA-9, the key point in process of LPS-induced severe inflammation

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About: Inhibition of SIRT1 by microRNA-9, the key point in process of LPS-induced severe inflammation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Inhibition of SIRT1 by microRNA-9, the key point in process of LPS-induced severe inflammation
Creator	Zhang, Wanfu Liu, Mingchuan Yin, Wen Bai, Xiaozhi Cao, Mengyuan »more»
source	Elsevier; Medline; PMC
abstract	Abstract Severe inflammation may lead to multiple organs dysfunction syndrome, which has a high mortality. MicroRNA is found participated in this process. In this study we developed a lipopolysaccharide-induced inflammation cell model on macrophages and a lipopolysaccharide-induced inflammation mouse model. It was found that during inflammation, microRNA-9 was increased, accompanied with the up-regulation of pro-inflammatory cytokines and anti-inflammatory cytokines. Down-regulation of microRNA-9 inhibited the up-regulation of inflammatory cytokines, promoted the up-regulation of anti-inflammatory cytokines and induced the remission of organ damage, showing a protective effect in inflammation. Bioinformatics analysis combined with luciferase reporter assay showed that SIRT1 was the target gene of microRNA-9. Transfection of microRNA-9 inhibitor could increase the level of SIRT1 and decrease the activation of NF-κB pathway in macrophages. Myeloid specific sirt1 knockout mice were included and we found that lack of SIRT1 in mice macrophages led to aggravated inflammation, cell apoptosis and organ injury, and eliminated the protective property of microRNA-9 inhibitor. In conclusion, we demonstrated that inhibition of microRNA-9 could alleviate inflammation through the up-regulation of SIRT1 and then suppressed the activation of NF-κB pathway. This is a meaningful explore about the specific mechanism of microRNA-9 in inflammation.
has issue date	2019-05-15(xsd:dateTime)
bibo:doi	10.1016/j.abb.2018.12.016
bibo:pmid	30552873
has license	els-covid
sha1sum (hex)	2654700a3429a7d7cd3f6c5e052edd175b7be5f8
schema:url	https://doi.org/10.1016/j.abb.2018.12.016
resource representing a document's title	Inhibition of SIRT1 by microRNA-9, the key point in process of LPS-induced severe inflammation
has PubMed Central identifier	PMC7094484
has PubMed identifier	30552873
schema:publication	Archives of Biochemistry and Biophysics
resource representing a document's body	covid:2654700a3429a7d7cd3f6c5e052edd175b7be5f8#body_text
is schema:about of	named entity 'POINT' named entity 'organs' named entity 'luciferase' named entity 'promoted' named entity 'NF-κB' »more»

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