About: Dynamic change of gene-to-gene regulatory networks in response to SARS-CoV-2 infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Dynamic change of gene-to-gene regulatory networks in response to SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Dynamic change of gene-to-gene regulatory networks in response to SARS-CoV-2 infection
Creator	Higashihara, Kako Nakazawa, Mai Okuno, Yasushi Tamada, Yoshinori Tanaka, Yoshihisa »more»
source	ArXiv
abstract	The current pandemic of SARS-CoV-2 has caused extensive damage to society. The characterization of SARS-CoV-2 profiles has been addressed by researchers globally with the aim of resolving this disruptive crisis. This investigation process is indispensable for an understanding of how SARS-CoV-2 behaves in human host cells. However, little is known about the systematic molecular mechanisms involved in the effect of SARS-CoV-2 infection on human host cells. Here, we have presented gene-to-gene regulatory networks in response to SARS-CoV-2 using a Bayesian network. We examined the dynamic changes of the SARS-CoV-2-purturbated networks established by our proposed framework for gene network analysis, revealing that interferon signaling gradually switches to the subsequent inflammatory-cytokine signaling cascades. Furthermore, we have succeeded in capturing a COVID-19 patient-specific network in which transduction of these signalings is coincidently induced. This enabled us to explore local regulatory systems influenced by SARS-CoV-2 in host cells more precisely at an individual level. Our panel of network analyses has provided new insight into SARS-CoV-2 research from the perspective of cellular systems.
has issue date	2020-08-21(xsd:dateTime)
has license	arxiv
sha1sum (hex)	25d5a57094c636c9b3b5893e08a1f96ec4d1e72a
resource representing a document's title	Dynamic change of gene-to-gene regulatory networks in response to SARS-CoV-2 infection
resource representing a document's body	covid:25d5a57094c636c9b3b5893e08a1f96ec4d1e72a#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'resolving' named entity 'signaling' named entity 'SARS-CoV-2' named entity 'analyses' »more»

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software