About: SARS-CoV originated from bats in 1998 and may still exist in humans

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About: SARS-CoV originated from bats in 1998 and may still exist in humans Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS-CoV originated from bats in 1998 and may still exist in humans
Creator	Zhang, Chiyu Zhong, Nanshan Liu, Jun Huang, Yuyi Li, Peilu »more»
source	ArXiv
abstract	SARS-CoV is believed to originate from civets and was thought to have been eliminated as a threat after the 2003 outbreak. Here, we show that human SARS-CoV (huSARS-CoV) originated directly from bats, rather than civets, by a cross-species jump in 1991, and formed a human-adapted strain in 1998. Since then huSARS-CoV has evolved further into highly virulent strains with genotype T and a 29-nt deletion mutation, and weakly virulent strains with genotype C but without the 29-nt deletion. The former can cause pneumonia in humans and could be the major causative pathogen of the SARS outbreak, whereas the latter might not cause pneumonia in humans, but evolved the ability to co-utilize civet ACE2 as an entry receptor, leading to interspecies transmission between humans and civets. Three crucial time points - 1991, for the cross-species jump from bats to humans; 1998, for the formation of the human-adapted SARS-CoV; and 2003, when there was an outbreak of SARS in humans - were found to associate with anomalously low annual precipitation and high temperatures in Guangdong. Anti-SARS-CoV sero-positivity was detected in 20% of all the samples tested from Guangzhou children who were born after 2005, suggesting that weakly virulent huSARS-CoVs might still exist in humans. These existing but undetected SARS-CoVs have a large potential to evolve into highly virulent strains when favorable climate conditions occur, highlighting a potential risk for the reemergence of SARS.
has issue date	2013-05-13(xsd:dateTime)
has license	arxiv
sha1sum (hex)	24b22b607f93d323774578d78f4f9d04bf53e26a
resource representing a document's title	SARS-CoV originated from bats in 1998 and may still exist in humans
resource representing a document's body	covid:24b22b607f93d323774578d78f4f9d04bf53e26a#body_text
is schema:about of	named entity 'formation' named entity 'samples' named entity 'detected' named entity 'civet' named entity 'paper' »more»

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