About: Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infection

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About: Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infection
Creator	Wang, Ming Sheng, Jie Tan, Wenjie Huang, Baoying Ye, Fei »more»
source	BioRxiv
abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a widespread outbreak of highly pathogenic COVID-19. It is therefore important and timely to characterize interactions between the virus and host cell at the molecular level to understand its disease pathogenesis. To gain insights, we performed high-throughput sequencing that generated time-series data simultaneously for bioinformatics analysis of virus genomes and host transcriptomes implicated in SARS-CoV-2 infection. Our analysis results showed that the rapid growth of the virus was accompanied by an early intensive response of host genes. We also systematically compared the molecular footprints of the host cells in response to SARS-CoV-2, SARS-CoV and MERS-CoV. Upon infection, SARS-CoV-2 induced hundreds of up-regulated host genes hallmarked by a significant cytokine production followed by virus-specific host antiviral responses. While the cytokine and antiviral responses triggered by SARS-CoV and MERS-CoV were only observed during the late stage of infection, the host antiviral responses during the SARS-CoV-2 infection were gradually enhanced lagging behind the production of cytokine. The early rapid host responses were potentially attributed to the high efficiency of SARS-CoV-2 entry into host cells, underscored by evidence of a remarkably up-regulated gene expression of TPRMSS2 soon after infection. Taken together, our findings provide novel molecular insights into the mechanisms underlying the infectivity and pathogenicity of SARS-CoV-2.
has issue date	2020-05-01(xsd:dateTime)
bibo:doi	10.1101/2020.04.30.071274
has license	biorxiv
sha1sum (hex)	23c8b3c03d7e8df89898145ddcac6944e941ffe5
schema:url	https://doi.org/10.1101/2020.04.30.071274
resource representing a document's title	Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infection
schema:publication	bioRxiv
resource representing a document's body	covid:23c8b3c03d7e8df89898145ddcac6944e941ffe5#body_text
is schema:about of	named entity 'Our' named entity 'performed' named entity 'high-throughput sequencing' named entity 'COVID-19' named entity 'transcriptome' »more»

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