About: Functional pathways in respiratory tract microbiome separate COVID-19 from community-acquired pneumonia patients

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About: Functional pathways in respiratory tract microbiome separate COVID-19 from community-acquired pneumonia patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Functional pathways in respiratory tract microbiome separate COVID-19 from community-acquired pneumonia patients
Creator	Parida, Laxmi Haiminen, Niina Seabolt, Ed Utro, Filippo
source	BioRxiv
abstract	In response to the global pandemic of the last four months, some progress has been made in understanding the molecular-level host interactions of the new coronavirus SARS-CoV-2 responsible for COVID-19. However, when the virus enters the body it interacts not only with the host but also with the micro-organisms already inhabiting the host. Understanding the virus-hostmicrobiome interactions can yield additional insights into the biological processes perturbed by the viral invasion. We carry out a comparative functional analysis of bronchoalveolar lavage fluid of eight COVID-19, twenty-five community-acquired pneumonia (CAP) patients and twenty healthy controls. The resulting functional profiles clearly separate the cohorts, even more sharply than just their corresponding taxonomic profiles. We also detect distinct pathway signatures in the respiratory tract microbiome that consistently distinguish COVID-19 patients from both the CAP and healthy cohorts. These include increased vitamin, drug, nucleotide, and energy metabolism during SARS-CoV-2 infection, contrasted with decreased amino acid and carbohydrate metabolism. This comparative analysis indicates consistent differences in COVID-19 respiratory tract metatranscriptomes compared to CAP and healthy samples.
has issue date	2020-05-05(xsd:dateTime)
bibo:doi	10.1101/2020.05.01.073171
has license	biorxiv
sha1sum (hex)	22bbb20ac3f96141fe6f89bcc3fca37b4fd1f0f5
schema:url	https://doi.org/10.1101/2020.05.01.073171
resource representing a document's title	Functional pathways in respiratory tract microbiome separate COVID-19 from community-acquired pneumonia patients
schema:publication	bioRxiv
resource representing a document's body	covid:22bbb20ac3f96141fe6f89bcc3fca37b4fd1f0f5#body_text
is schema:about of	named entity 'samples' named entity 'carbohydrate metabolism' named entity 'host' named entity 'CAP' named entity 'pandemic' »more»

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