About: Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19

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About: Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19
Creator	Shi, Yi Jiang, Li Gong, Bo Huang, Lulin Jiang, Qi »more»
source	MedRxiv
abstract	The coronavirus disease 2019 (COVID-19) outbreak is an ongoing global health emergence, but the pathogenesis remains unclear. We revealed blood cell immune response profiles using 5' mRNA, TCR and BCR V(D)J transcriptome analysis with single-cell resolution. Data from 134,620 PBMCs and 83,387 TCR and 12,601 BCR clones was obtained, and 56 blood cell subtypes and 23 new cell marker genes were identified from 16 participants. The number of specific subtypes of immune cells changed significantly when compared patients with controls. Activation of the interferon-MAPK pathway is the major defense mechanism, but MAPK transcription signaling is inhibited in cured patients. TCR and BCR V(D)J recombination is highly diverse in generating different antibodies against SARS-CoV-2. Therefore, the interferon-MAPK pathway and TCR- and BCR-produced antibodies play important roles in the COVID-19 immune response. Immune deficiency or immune over-response may result in the condition of patients with COVID-19 becoming critical or severe.
has issue date	2020-03-17(xsd:dateTime)
bibo:doi	10.1101/2020.03.15.20033472
has license	medrxiv
sha1sum (hex)	20a1d878639ad14f6ecffab84a56c223946cb081
schema:url	https://doi.org/10.1101/2020.03.15.20033472
resource representing a document's title	Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19
resource representing a document's body	covid:20a1d878639ad14f6ecffab84a56c223946cb081#body_text
is schema:about of	named entity 'condition' named entity 'SARS-CoV-2' named entity 'transcription' named entity 'compared' named entity 'transcriptome' »more»

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