About: TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection

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About: TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection
Creator	Song, Kun Li, Shitao Patil, Girish Hao, Wenzhuo Wang, Lingyan »more»
source	PMC
abstract	Vesicular stomatitis virus (VSV) is a zoonotic, negative-stranded RNA virus of the family Rhabdoviridae. The nucleoprotein (N) of VSV protects the viral genomic RNA and plays an essential role in viral transcription and replication, which makes the nucleoprotein an ideal target of host defense. However, whether and how host innate/intrinsic immunity limits VSV infection by targeting the N protein are unknown. In this study, we found that the N protein of VSV (VSV-N) interacted with a ubiquitin E3 ligase, tripartite motif protein 41 (TRIM41). Overexpression of TRIM41 inhibited VSV infection. Conversely, the depletion of TRIM41 increased host susceptibility to VSV. Furthermore, the E3 ligase defective mutant of TRIM41 failed to limit VSV infection, suggesting the requirement of the E3 ligase activity of TRIM41 in viral restriction. Indeed, TRIM41 ubiquitinated VSV-N in cells and in vitro. TRIM41-mediated ubiquitination leads to the degradation of VSV-N through proteasome, thereby limiting VSV infection. Taken together, our study identifies TRIM41 as a new intrinsic immune factor against VSV by targeting the viral nucleoprotein for ubiquitination and subsequent protein degradation.
has issue date	2020-01-22(xsd:dateTime)
bibo:doi	10.3390/v12020131
bibo:pmid	31979016
has license	cc-by
sha1sum (hex)	1f1bfc20d5fa1896482283874f8b7971e51426ec
schema:url	https://doi.org/10.3390/v12020131
resource representing a document's title	TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection
has PubMed Central identifier	PMC7077221
has PubMed identifier	31979016
schema:publication	Viruses
resource representing a document's body	covid:1f1bfc20d5fa1896482283874f8b7971e51426ec#body_text
is schema:about of	named entity 'protein' named entity 'inhibited' named entity 'E3 ligase' named entity 'targeting' named entity 'infection' »more»

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