About: APOBEC3G directly binds Hepatitis B virus core protein in cell and cell free systems

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About: APOBEC3G directly binds Hepatitis B virus core protein in cell and cell free systems Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	APOBEC3G directly binds Hepatitis B virus core protein in cell and cell free systems
Creator	Chen, Feng Li, Jie Chen, Zhi Yang, Zhenggang Li, Shuping »more»
topic	covid:1f0097fb57b078c0e81d219f65f218d571314be2#this
source	Elsevier; Medline; PMC
abstract	Abstract APOBEC3G (A3G) is an intrinsic antiretroviral factor which can inhibit Hepatitis B virus (HBV) replication. This antiviral activity mainly depends on A3G incorporation into viral particles. However, the mechanisms of A3G packaging into HBV particles have not been well characterized. In this paper, we demonstrated that A3G interacted with the HBV core protein (HBc) directly in co-transfected HepG2 cells using the fluorescence resonance energy transfer (FRET) approach. In addition, we further found that this interaction did not require other factors in vitro using surface plasmon resonance (SPR) technology on BIAcore 3000. While cellular RNA or viral RNA was added to A3G protein solution before flow through the BIAcore chip, the interaction was not affected. In conclusion, these results suggest the possibility that A3G is incorporated into HBV viral particles via direct binding with HBc protein.
has issue date	2010-08-31(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2010.05.009
bibo:pmid	20510315
has license	els-covid
sha1sum (hex)	1f0097fb57b078c0e81d219f65f218d571314be2
schema:url	https://doi.org/10.1016/j.virusres.2010.05.009
resource representing a document's title	APOBEC3G directly binds Hepatitis B virus core protein in cell and cell free systems
has PubMed Central identifier	PMC7173111
has PubMed identifier	20510315
schema:publication	Virus Research
resource representing a document's body	covid:1f0097fb57b078c0e81d219f65f218d571314be2#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/1f0097fb57b078c0e81d219f65f218d571314be2
is schema:about of	named entity 'HBV' named entity 'particles' named entity 'This' named entity 'fluorescence' named entity 'intrinsic' »more»

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