About: Deficient Incorporation of Spike Protein into Virions Contributes to the Lack of Infectivity Following Establishment of a Persistent, Non-Productive Infection in Oligodendroglial Cell Culture by Murine Coronavirus

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About: Deficient Incorporation of Spike Protein into Virions Contributes to the Lack of Infectivity Following Establishment of a Persistent, Non-Productive Infection in Oligodendroglial Cell Culture by Murine Coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Deficient Incorporation of Spike Protein into Virions Contributes to the Lack of Infectivity Following Establishment of a Persistent, Non-Productive Infection in Oligodendroglial Cell Culture by Murine Coronavirus
Creator	Liu, Yin Cao, Jianzhong Zhang, Xuming Herbst, Werner
source	Elsevier; Medline; PMC
abstract	Infection of mouse oligodendrocytes with a recombinant mouse hepatitis virus (MHV) expressing a green fluorescence protein facilitated specific selection of virus-infected cells and subsequent establishment of persistence. Interestingly, while viral genomic RNAs persisted in infected cells over 14 subsequent passages with concomitant synthesis of viral subgenomic mRNAs and structural proteins, no infectious virus was isolated beyond passage 2. Further biochemical and electron microscopic analyses revealed that virions, while assembled, contained little spike in the envelope, indicating that lack of infectivity during persistence was likely due to deficiency in spike incorporation. This type of non-lytic, non-productive persistence in oligodendrocytes is unique among animal viruses and resembles MHV persistence previously observed in the mouse central nervous system. Thus, establishment of such a culture system that can recapitulate the in vivo phenomenon will provide a powerful approach for elucidating the mechanisms of coronavirus persistence in glial cells at the cellular and molecular levels.
has issue date	2011-01-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2010.10.006
bibo:pmid	21035161
has license	bronze-oa
sha1sum (hex)	1b5064ad9a2828b30813ac5634d98b5da2f1d3d9
schema:url	https://doi.org/10.1016/j.virol.2010.10.006
resource representing a document's title	Deficient Incorporation of Spike Protein into Virions Contributes to the Lack of Infectivity Following Establishment of a Persistent, Non-Productive Infection in Oligodendroglial Cell Culture by Murine Coronavirus
has PubMed Central identifier	PMC3032362
has PubMed identifier	21035161
schema:publication	Virology
resource representing a document's body	covid:1b5064ad9a2828b30813ac5634d98b5da2f1d3d9#body_text
is schema:about of	named entity 'analyses' named entity 'spike' named entity 'Further' named entity 'type' named entity 'Thus' »more»

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