About: Efficient adaptive designs for clinical trials of interventions for COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Efficient adaptive designs for clinical trials of interventions for COVID-19
Creator	Whitehead, John Jaki, Thomas Friede, Tim Krisam, Johannes Stallard, Nigel »more»
source	ArXiv
abstract	The COVID-19 pandemic has led to an unprecedented response in terms of clinical research activity. An important part of this research has been focused on randomized controlled clinical trials to evaluate potential therapies for COVID-19. The results from this research need to be obtained as rapidly as possible. This presents a number of challenges associated with considerable uncertainty over the natural history of the disease and the number and characteristics of patients affected, and the emergence of new potential therapies. These challenges make adaptive designs for clinical trials a particularly attractive option. Such designs allow a trial to be modified on the basis of interim analysis data or stopped as soon as sufficiently strong evidence has been observed to answer the research question, without compromising the trial's scientific validity or integrity. In this paper we describe some of the adaptive design approaches that are available and discuss particular issues and challenges associated with their use in the pandemic setting. Our discussion is illustrated by details of four ongoing COVID-19 trials that have used adaptive designs.
has issue date	2020-05-25(xsd:dateTime)
has license	arxiv
sha1sum (hex)	166b81f0009a928d69d2717fa97260e51ca8a2b7
resource representing a document's title	Efficient adaptive designs for clinical trials of interventions for COVID-19
resource representing a document's body	covid:166b81f0009a928d69d2717fa97260e51ca8a2b7#body_text
is schema:about of	named entity 'controlled clinical trials' named entity 'uncertainty' named entity 'activity' named entity 'compromising' named entity 'Efficient' »more»

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