About: RNA sequencing demonstrates large-scale temporal dysregulation of gene expression in stimulated macrophages derived from MHC-defined chicken haplotypes

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About: RNA sequencing demonstrates large-scale temporal dysregulation of gene expression in stimulated macrophages derived from MHC-defined chicken haplotypes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	RNA sequencing demonstrates large-scale temporal dysregulation of gene expression in stimulated macrophages derived from MHC-defined chicken haplotypes
Creator	Bryden, Randall Clark, Jory Collisson, Ellen Downs, Eileen Drechsler, Yvonne »more»
source	Medline; PMC
abstract	Discovering genetic biomarkers associated with disease resistance and enhanced immunity is critical to developing advanced strategies for controlling viral and bacterial infections in different species. Macrophages, important cells of innate immunity, are directly involved in cellular interactions with pathogens, the release of cytokines activating other immune cells and antigen presentation to cells of the adaptive immune response. IFNγ is a potent activator of macrophages and increased production has been associated with disease resistance in several species. This study characterizes the molecular basis for dramatically different nitric oxide production and immune function between the B2 and the B19 haplotype chicken macrophages.A large-scale RNA sequencing approach was employed to sequence the RNA of purified macrophages from each haplotype group (B2 vs. B19) during differentiation and after stimulation. Our results demonstrate that a large number of genes exhibit divergent expression between B2 and B19 haplotype cells both prior and after stimulation. These differences in gene expression appear to be regulated by complex epigenetic mechanisms that need further investigation.
has issue date	2017-08-28(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0179391
bibo:pmid	28846708
has license	cc-by
sha1sum (hex)	160c4bd7c9401bed81b339157fa4ab54242ca8ff
schema:url	https://doi.org/10.1371/journal.pone.0179391
resource representing a document's title	RNA sequencing demonstrates large-scale temporal dysregulation of gene expression in stimulated macrophages derived from MHC-defined chicken haplotypes
has PubMed Central identifier	PMC5573159
has PubMed identifier	28846708
schema:publication	PLoS One
resource representing a document's body	covid:160c4bd7c9401bed81b339157fa4ab54242ca8ff#body_text
is schema:about of	named entity 'LARGE' named entity 'CHICKEN' named entity 'B19' named entity 'PRODUCTION' named entity 'BIOMARKERS' »more»

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